Mild to moderate pain

Active Ingredient: Codeine

Indication for Codeine

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

Codeine is indicated in patients older than 12 years of age for the treatment of acute moderate pain which is not considered to be relieved by other analgesics such as paracetamol or ibuprofen alone.

For this indication, competent medicine agencies globally authorize below treatments:

30 mg 1-4 times daily for up to 3 days

For:

Dosage regimens

Oral, 30 milligrams codeine, 1 to 4 times daily, over the duration of 1 to 3 days. The maximum allowed total dose is 240 milligrams codeine daily.

Detailed description

The usual dose is 30 mg, repeated 6 hourly as required.

Codeine should be used at the lowest effective dose for the shortest period of time. This dose may be taken, up to 4 times a day at intervals of not less than 6 hours. Maximum daily dose should not exceed 240 mg.

The duration of treatment should be limited to 3 days and if no effective pain relief is achieved the patients/carers should be advised to seek the views of a physician.

Elderly

A reduced dosage may be necessary.

0.5-1 mg/kg of body weight, every 4-6 hours for up to 3 days

For:

Dosage regimens

Regimen A: Oral, between 0.5 milligrams codeine per kilogram of body weight and 1 milligrams codeine per kilogram of body weight, once every 4 to 6 hours, over the duration of 1 to 3 days.

Regimen B: Oral, between 30 milligrams codeine and 60 milligrams codeine, once every 6 hours.

Detailed description

The recommended codeine dose for children 12 years and older should be 30 to 60 mg every 6 hours when necessary up to a maximum dose of 240 mg daily. The dose is based on the body weight (0.5-1 mg/kg).

Active ingredient

Codeine

Codeine is a centrally acting weak analgesic. Codeine exerts its effect through μ opioid receptors, although codeine has low affinity for these receptors, and its analgesic effect is due to its conversion to morphine. Codeine, particularly in combination with other analgesics such as paracetamol, has been shown to be effective in acute nociceptive pain. The anti-tussive activity of codeine is probably due to its depressant effect on the medullary cough centre in the brain.

Read more about Codeine

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