Schizophrenia

Active Ingredient: Iloperidone

Indication for Iloperidone

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

1 mg twice daily on Day 1, 2 mg twice daily on Day 2, 4 mg twice daily on Day 3, 6 mg twice daily on Day 4, 8 mg twice daily on Day 5, 10 mg twice daily on Day 6, 12 mg twice daily on Day 7 and 6-12 mg twice daily thereafter

For:

Dosage regimens

Oral, 1 milligrams iloperidone, 2 times daily, over the duration of 1 day. Afterwards, oral, 2 milligrams iloperidone, 2 times daily, over the duration of 1 day. Afterwards, oral, 4 milligrams iloperidone, 2 times daily, over the duration of 1 day. Afterwards, oral, 6 milligrams iloperidone, 2 times daily, over the duration of 1 day. Afterwards, oral, 8 milligrams iloperidone, 2 times daily, over the duration of 1 day. Afterwards, oral, 10 milligrams iloperidone, 2 times daily, over the duration of 1 day. Afterwards, oral, 12 milligrams iloperidone, 2 times daily, over the duration of 1 day. Afterwards, oral, between 6 milligrams iloperidone and 12 milligrams iloperidone, 2 times daily.

Detailed description

Titrate iloperidone to avoid orthostatic hypotension. The table below includes dosage recommendations for iloperidone for the treatment of schizophrenia in adults.

Dosage recommendations for iloperidone in adults for the treatment of schizophrenia:

Indication and
population
Titration schedule Recommended
dosage
Day 1Day 2 Day 3 Day 4 Day 5 Day 6 Day 7
Schizophrenia 1mg
twice
daily
2 mg
twice
daily
4 mg
twice
daily
6 mg
twice
daily
8 mg
twice
daily
10 mg
twice
daily
12 mg
twice
daily
6 mg to 12 mg
twice daily

Reinitiation of treatment in patients previously discontinued

Although there are no data to specifically address reinitiation of treatment, it is recommended that the initiation titration schedule be followed whenever patients have had an interval off iloperidone of more than 3 days.

Dosage considerations

Administer iloperidone orally with or without food.

Active ingredient

Iloperidone

The mechanism of action of iloperidone in schizophrenia and bipolar I disorder is unknown. However, the efficacy of iloperidone could be mediated through a combination of dopamine type 2 (D2) and serotonin type 2 (5-HT2) antagonism. Iloperidone forms an active metabolite, P88, that has an in vitro receptor binding profile similar to the parent drug.

Read more about Iloperidone

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