Geographic atrophy secondary to age-related macular degeneration

Active Ingredient: Avacincaptad pegol

Indication for Avacincaptad pegol

Population group: only elderly (65 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

2 mg to each affected eye once monthly for up to 12 months

For:

Dosage regimens

Intravitreal, 2 milligrams avacincaptad pegol, once monthly, over the duration of 12 months.

Detailed description

The recommended dose for avacincaptad pegol is 2 mg administered by intravitreal injection to each affected eye once monthly (approximately every 28 ± 7 days) for up to 12 months.

Prior to the intravitreal injection, patients should be monitored for elevated intraocular pressure (IOP) using tonometry. If necessary, ocular hypotensive medication can be given to lower the IOP.

Immediately following the intravitreal injection, patients should be monitored for elevation in intraocular pressure (IOP). Appropriate monitoring may consist of a check for perfusion of the optic nerve head or tonometry.

Following intravitreal injection, patients should be instructed to report any symptoms suggestive of endophthalmitis (e.g., eye pain, redness of the eye, photophobia, blurring of vision) without delay.

Active ingredient

Avacincaptad pegol

Avacincaptad pegol is an RNA aptamer, a PEGylated oligonucleotide that binds to and inhibits complement protein C5. By inhibiting C5, avacincaptad pegol may prevent its cleavage to C5a and C5b thus decreasing membrane attack complex (MAC) formation.

Read more about Avacincaptad pegol

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