This brand name is authorized in Austria, Australia, Canada, Germany, Estonia, Spain, France, Croatia, Ireland, Italy, Japan, Lithuania, Netherlands, New Zealand, Poland, United Kingdom, United States
The drug ADCIRCA contains one active pharmaceutical ingredient (API):
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1
Tadalafil
UNII 742SXX0ICT - TADALAFIL
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Tadalafil is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by tadalafil produces increased levels of cGMP in the corpus cavernosum. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. The effect of PDE5 inhibition on cGMP concentration in the corpus cavernosum is also observed in the smooth muscle of the prostate, the bladder and their vascular supply. The resulting vascular relaxation increases blood perfusion which may be the mechanism by which symptoms of benign prostatic hyperplasia are reduced. |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| G04BE08 | Tadalafil | G Genito urinary system and sex hormones → G04 Urologicals → G04B Other urologicals, incl. antispasmodics → G04BE Drugs used in erectile dysfunction |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: AU | Pharmaceutical Benefits Scheme | Identifier(s): 12150L, 12151M, 1304P, 1308W |
| Country: CA | Health Products and Food Branch | Identifier(s): 02338327 |
| Country: DE | Bundesinstitut für Arzneimittel und Medizinprodukte | Identifier(s): 05908891, 05908916, 10536687 |
| Country: EE | Ravimiamet | Identifier(s): 1460225, 1460236 |
| Country: ES | Centro de información online de medicamentos de la AEMPS | Identifier(s): 08476006 |
| Country: FR | Base de données publique des médicaments | Identifier(s): 63206355 |
| Country: GB | Medicines & Healthcare Products Regulatory Agency | Identifier(s): 182492 |
| Country: IE | Health Products Regulatory Authority | Identifier(s): 88530 |
| Country: IT | Agenzia del Farmaco | Identifier(s): 039598026 |
| Country: JP | 医薬品医療機器総合機構 | Identifier(s): 2190030F1029 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1056532, 1056533 |
| Country: NL | Z-Index G-Standaard, PRK | Identifier(s): 68241 |
| Country: NZ | Medicines and Medical Devices Safety Authority | Identifier(s): 15164 |
| Country: PL | Rejestru Produktów Leczniczych | Identifier(s): 100206193 |
| Country: US | FDA, National Drug Code | Identifier(s): 43353-070, 66302-467 |
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