AERRANE

This brand name is authorized in Estonia, France, Hong Kong SAR China, New Zealand, Poland, Romania, Singapore, South Africa, Spain, Tunisia, UK.

Active ingredients

The drug AERRANE contains one active pharmaceutical ingredient (API):

1
UNII CYS9AKD70P - ISOFLURANE
 

Isoflurane is a general inhalational anaesthetic for use in induction and maintenance. Isoflurane provides rapid induction of anaesthesia and also rapid recovery.

Isoflurane is a fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may also both inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake, and potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery.

 
Read more about Isoflurane

Medication package inserts

Below package inserts are available for further reading:

Document Type Information Source  
 AERRANE Liquid for inhalation MPI, EU: SmPC Medicines & Healthcare Products Regulatory Agency (GB)

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC Group Classification
N01AB06 Isoflurane N Nervous system → N01 Anesthetics → N01A Anesthetics, general → N01AB Halogenated hydrocarbons
Discover more medicines within N01AB06

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
EE Ravimiamet 1024175, 1074372
ES Centro de información online de medicamentos de la AEMPS 60378
FR Base de données publique des médicaments 63498500
GB Medicines & Healthcare Products Regulatory Agency 60018
HK Department of Health Drug Office 50667
NZ Medicines and Medical Devices Safety Authority 3904
PL Rejestru Produktów Leczniczych 100110464
RO Agenția Națională a Medicamentului și a Dispozitivelor Medicale W43418001, W43418002
SG Health Sciences Authority 08670P
TN Direction de la Pharmacie et du Médicament 10153011H
ZA Health Products Regulatory Authority 31/2.1/0341

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