This brand name is authorized in Austria, Estonia, Spain, France, Croatia, Ireland, Italy, Lithuania, Poland, Romania
The drug ASPAVELI contains one active pharmaceutical ingredient (API):
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Pegcetacoplan
UNII TO3JYR3BOU - PEGCETACOPLAN
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Pegcetacoplan is a symmetrical molecule comprised of two identical pentadecapeptides covalently bound to the ends of a linear 40-kDa PEG molecule. The peptide moieties bind to complement C3 and exert a broad inhibition of the complement cascade. Pegcetacoplan binds to complement protein C3 and its activation fragment C3b with high affinity, thereby regulating the cleavage of C3 and the generation of downstream effectors of complement activation. In PNH, extravascular haemolysis (EVH) is facilitated by C3b opsonisation while intravascular haemolysis (IVH) is mediated by the downstream membrane attack complex (MAC). |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| ASPAVELI Solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L04AJ03 | L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AJ Complement inhibitors | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: EE | Ravimiamet | Identifier(s): 1871951, 1871962 |
| Country: ES | Centro de información online de medicamentos de la AEMPS | Identifier(s): 1211595001 |
| Country: FR | Base de données publique des médicaments | Identifier(s): 67568483 |
| Country: IT | Agenzia del Farmaco | Identifier(s): 049750019, 049750021 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1093846, 1093847 |
| Country: PL | Rejestru Produktów Leczniczych | Identifier(s): 100463504 |
| Country: RO | Agenția Națională a Medicamentului și a Dispozitivelor Medicale | Identifier(s): W68382001, W68382002 |
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