This brand name is authorized in United States
The drug AYVAKIT contains one active pharmaceutical ingredient (API):
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1
Avapritinib
UNII 513P80B4YJ - AVAPRITINIB
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Avapritinib is a tyrosine kinase inhibitor that targets PDGFRA and PDGFRA D842 mutants as well as multiple KIT exon 11, 11/17 and 17 mutants with half maximal inhibitory concentrations (IC50s) less than 25 nM. Certain mutations in PDGFRA and KIT can result in the autophosphorylation and constitutive activation of these receptors which can contribute to tumor cell proliferation. Other potential targets for avapritinib include wild type KIT, PDGFRB, and CSFR1. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| AYVAKIT Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: US | FDA, National Drug Code | Identifier(s): 72064-110, 72064-120, 72064-130 |
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