This brand name is authorized in Austria, Estonia, France, Croatia, Ireland, Lithuania, Poland, Romania, United Kingdom
The drug AYVAKYT contains one active pharmaceutical ingredient (API):
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1
Avapritinib
UNII 513P80B4YJ - AVAPRITINIB
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Avapritinib is a tyrosine kinase inhibitor that targets PDGFRA and PDGFRA D842 mutants as well as multiple KIT exon 11, 11/17 and 17 mutants with half maximal inhibitory concentrations (IC50s) less than 25 nM. Certain mutations in PDGFRA and KIT can result in the autophosphorylation and constitutive activation of these receptors which can contribute to tumor cell proliferation. Other potential targets for avapritinib include wild type KIT, PDGFRB, and CSFR1. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| AYVAKYT Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01EX18 | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EX Other protein kinase inhibitors | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: EE | Ravimiamet | Identifier(s): 1828201, 1828212, 1828223, 1878509, 1878510 |
| Country: FR | Base de données publique des médicaments | Identifier(s): 63189920, 64069767, 65304816 |
| Country: GB | Medicines & Healthcare Products Regulatory Agency | Identifier(s): 390640, 390643, 390648 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1091244, 1091245, 1091246 |
| Country: PL | Rejestru Produktów Leczniczych | Identifier(s): 100441847, 100441853, 100441860 |
| Country: RO | Agenția Națională a Medicamentului și a Dispozitivelor Medicale | Identifier(s): W69470001, W69471001, W69472001, W69473001, W69474001 |
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