BOSULIF

This brand name is authorized in Austria, Canada, Cyprus, Estonia, Spain, Finland, France, Croatia, Ireland, Israel, Japan, Lithuania, Netherlands, Poland, Romania, Turkey, United Kingdom, United States

Active ingredients

The drug BOSULIF contains one active pharmaceutical ingredient (API):

1 Bosutinib UNII 844ZJE6I55 - BOSUTINIB MONOHYDRATE

Bosutinib belongs to a pharmacological class of medicinal products known as kinase inhibitors. Bosutinib inhibits the abnormal BCR-ABL kinase that promotes CML. Modeling studies indicate that bosutinib binds the kinase domain of BCR-ABL. Bosutinib is also an inhibitor of Src family kinases including Src, Lyn and Hck. Bosutinib minimally inhibits platelet-derived growth factor (PDGF) receptor and c-Kit. In in vitro studies, bosutinib inhibits proliferation and survival of established CML cell lines, Ph+ ALL cell lines, and patient-derived primary primitive CML cells. Read about Bosutinib

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
BOSULIF Film-coated tablet	European Medicines Agency (EU)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
L01EA04	Bosutinib	L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EA BCR-ABL tyrosine kinase inhibitors
Discover more medicines within L01EA04

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: CA	Health Products and Food Branch	Identifier(s): 02419149, 02419157
Country: EE	Ravimiamet	Identifier(s): 1612055, 1612066, 1612077, 1612088, 1665468, 1773121, 1773132
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 113818001, 113818003, 113818006
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 479904, 492377, 558417
Country: FR	Base de données publique des médicaments	Identifier(s): 60462965, 61669899, 63150294
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 226977, 226980, 355976
Country: IE	Health Products Regulatory Authority	Identifier(s): 88032, 88107
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 7661, 7662, 8714
Country: JP	医薬品医療機器総合機構	Identifier(s): 4291036F1028
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1069897, 1069898, 1069899, 1069900, 1074112, 1088046, 1088047
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 106070, 106089, 151041
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100297089, 100297095, 100417145
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W64815001, W64816001, W67871001
Country: TR	İlaç ve Tıbbi Cihaz Kurumu	Identifier(s): 8681308097446, 8681308097453, 8681308097613, 8681308097620, 8681308097637
Country: US	FDA, National Drug Code	Identifier(s): 0069-0135, 0069-0136, 0069-0193, 63539-117