COMBIGAN

This brand name is authorized in Austria, Australia, Brazil, Canada, Ecuador, Estonia, Spain, Finland, France, Hong Kong, Croatia, Ireland, Israel, Italy, Lithuania, Mexico, Netherlands, New Zealand, Poland, Romania, Singapore, Tunisia, Turkey, United Kingdom, United States, South Africa

Active ingredients

The drug COMBIGAN contains a combination of these active pharmaceutical ingredients (APIs):

1 Brimonidine UNII 4S9CL2DY2H - BRIMONIDINE TARTRATE

Brimonidine is an alpha2-adrenergic receptor agonist that is 1000-fold more selective for the alpha2-adrenoceptor than the alpha1-adrenoreceptor. This selectivity results in no mydriasis and the absence of vasoconstriction in microvessels associated with human retinal xenografts. Read about Brimonidine

2 Timolol UNII P8Y54F701R - TIMOLOL MALEATE

Timolol is a non-selective beta-adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anaesthetic activity. Timolol reduces intra-ocular pressure, whether or not this is associated with glaucoma. Read about Timolol

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
COMBIGAN Eye drops, solution	Medicines & Healthcare Products Regulatory Agency (GB)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
S01ED51	Timolol, combinations	S Sensory organs → S01 Ophthalmologicals → S01E Antiglaucoma preparations and miotics → S01ED Beta blocking agents
Discover more medicines within S01ED51

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: AU	Pharmaceutical Benefits Scheme	Identifier(s): 5535H, 8826M
Country: BR	Câmara de Regulação do Mercado de Medicamentos	Identifier(s): 501006001173319, 501006002171311
Country: CA	Health Products and Food Branch	Identifier(s): 02248347
Country: EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	Identifier(s): 27.158-07-06
Country: EE	Ravimiamet	Identifier(s): 1618635, 1618646
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 67438
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 036833, 050560
Country: FR	Base de données publique des médicaments	Identifier(s): 60657189
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 114771, 195414, 198693, 375750, 92069
Country: HK	Department of Health Drug Office	Identifier(s): 56799
Country: HR	Agencija za lijekove i medicinske proizvode	Identifier(s): HR-H-496659610
Country: IE	Health Products Regulatory Authority	Identifier(s): 14312, 14320
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 6069
Country: IT	Agenzia del Farmaco	Identifier(s): 037083019
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1071092, 1072277
Country: MX	Comisión Federal para la Protección contra Riesgos Sanitarios	Identifier(s): 627M2005
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 81159
Country: NZ	Medicines and Medical Devices Safety Authority	Identifier(s): 11390
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100159482
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W69265001, W69265002
Country: SG	Health Sciences Authority	Identifier(s): 13406P
Country: TN	Direction de la Pharmacie et du Médicament	Identifier(s): 3983031
Country: TR	İlaç ve Tıbbi Cihaz Kurumu	Identifier(s): 8699490561102
Country: US	FDA, National Drug Code	Identifier(s): 0023-9211
Country: ZA	Health Products Regulatory Authority	Identifier(s): A39/15.4/0464