COMBIGAN

This brand name is authorized in United States. It is also authorized in Australia, Austria, Brazil, Canada, Croatia, Ecuador, Estonia, Finland, France, Hong Kong SAR China, Ireland, Israel, Italy, Lithuania, Mexico, Netherlands, New Zealand, Poland, Romania, Singapore, South Africa, Spain, Tunisia, Turkey, UK.

Active ingredients

The drug COMBIGAN contains a combination of these active pharmaceutical ingredients (APIs):

1	Brimonidine UNII 4S9CL2DY2H - BRIMONIDINE TARTRATE
	Brimonidine is an alpha2-adrenergic receptor agonist that is 1000-fold more selective for the alpha2-adrenoceptor than the alpha1-adrenoreceptor. This selectivity results in no mydriasis and the absence of vasoconstriction in microvessels associated with human retinal xenografts.
	Read more about Brimonidine
2	Timolol UNII P8Y54F701R - TIMOLOL MALEATE
	Timolol is a non-selective beta-adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anaesthetic activity. Timolol reduces intra-ocular pressure, whether or not this is associated with glaucoma.
	Read more about Timolol

Medication package inserts

Below package inserts are available for further reading:

Document	Type	Information Source
COMBIGAN Eye drops, solution	MPI, EU: SmPC	Medicines & Healthcare Products Regulatory Agency (GB)

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC Group		Classification
S01ED51	Timolol, combinations	S Sensory organs → S01 Ophthalmologicals → S01E Antiglaucoma preparations and miotics → S01ED Beta blocking agents
Discover more medicines within S01ED51

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
AU	Pharmaceutical Benefits Scheme	5535H, 8826M
BR	Câmara de Regulação do Mercado de Medicamentos	501006001173319, 501006002171311
CA	Health Products and Food Branch	02248347
EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	27.158-07-06
EE	Ravimiamet	1618635, 1618646
ES	Centro de información online de medicamentos de la AEMPS	67438
FI	Lääkealan turvallisuus- ja kehittämiskeskus	036833, 050560
FR	Base de données publique des médicaments	60657189
GB	Medicines & Healthcare Products Regulatory Agency	114771, 195414, 198693, 375750, 92069
HK	Department of Health Drug Office	56799
HR	Agencija za lijekove i medicinske proizvode	HR-H-496659610
IE	Health Products Regulatory Authority	14312, 14320
IL	מִשְׂרַד הַבְּרִיאוּת	6069
IT	Agenzia del Farmaco	037083019
LT	Valstybinė vaistų kontrolės tarnyba	1071092, 1072277
MX	Comisión Federal para la Protección contra Riesgos Sanitarios	627M2005
NL	Z-Index G-Standaard, PRK	81159
NZ	Medicines and Medical Devices Safety Authority	11390
PL	Rejestru Produktów Leczniczych	100159482
RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	W69265001, W69265002
SG	Health Sciences Authority	13406P
TN	Direction de la Pharmacie et du Médicament	3983031
TR	İlaç ve Tıbbi Cihaz Kurumu	8699490561102
US	FDA, National Drug Code	0023-9211
ZA	Health Products Regulatory Authority	A39/15.4/0464