This brand name is authorized in United States. It is also authorized in Austria, Canada, Ecuador, Hong Kong SAR China, Mexico, Netherlands, Singapore, South Africa, UK.
The drug COMBIVENT contains a combination of these active pharmaceutical ingredients (APIs):
1
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UNII
J697UZ2A9J - IPRATROPIUM BROMIDE
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Ipratropium is a quaternary ammonium compound with anticholinergic (parasympatholytic) properties. Ipratropium appears to inhibit vagally mediated reflexes by antagonising the action of acetylcholine, the transmitter agent released from the vagus nerve. Anticholinergics prevent the increase in intracellular concentration of Ca++, which is caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle. Ca++ release is mediated by the second messenger system consisting of IP3 (inositol triphosphate) and DAG (diacylglycerol). |
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2
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UNII
021SEF3731 - ALBUTEROL SULFATE
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Salbutamol is a selective β2-agonist providing short-acting (4-6 hour) bronchodilation with a fast onset (within 5 minutes) in reversible airways obstruction. At therapeutic doses it acts on the β2-adrenoceptors of bronchial muscle. Salbutamol is administered for the symptomatic relief of bronchospasm associated with chronic or acute asthma, bronchitis or other obstructive pulmonary diseases. |
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Below package inserts are available for further reading:
| Document | Type | Information Source | |
|---|---|---|---|
| COMBIVENT RESPIMAT Inhalation spray | MPI, US: SPL/PLR | FDA, National Drug Code (US) |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC Group | Classification | |
|---|---|---|
| R03AL02 | Salbutamol and ipratropium bromide | R Respiratory system → R03 Drugs for obstructive airway diseases → R03A Adrenergics, inhalants → R03AL Adrenergics in combination with anticholinergics |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| CA | Health Products and Food Branch | 02419106 |
| EC | Agencia Nacional de Regulación, Control y Vigilancia Sanitaria | 29859-06-11 |
| GB | Medicines & Healthcare Products Regulatory Agency | 195416, 198695, 34064, 373645, 376257 |
| HK | Department of Health Drug Office | 41964 |
| MX | Comisión Federal para la Protección contra Riesgos Sanitarios | 261M97 |
| NL | Z-Index G-Standaard | 14172348 |
| NL | Z-Index G-Standaard, PRK | 81760 |
| SG | Health Sciences Authority | 09558P |
| US | FDA, National Drug Code | 0597-0024 |
| ZA | Health Products Regulatory Authority | 30/10.2.1/0476 |
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