This brand name is authorized in United States. It is also authorized in Canada, Ecuador, Hong Kong SAR China, New Zealand.
The drug CONTRAVE contains a combination of these active pharmaceutical ingredients (APIs):
1
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UNII
Z6375YW9SF - NALTREXONE HYDROCHLORIDE
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Naltrexone is an orally used, long acting specific opioid antagonist. Naltrexone binds competitively to receptors which are located in the central and peripheral nervous system and hence blocks the access for exogenously administered opioids. |
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2
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UNII
ZG7E5POY8O - BUPROPION HYDROCHLORIDE
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Bupropion is a selective inhibitor of the neuronal re-uptake of catecholamines (noradrenaline and dopamine) with minimal effect on the re-uptake of indolamines (serotonin) and does not inhibit either monoamine oxidase. The mechanism by which bupropion enhances the ability of patients to abstain from smoking is unknown. However, it is presumed that this action is mediated by noradrenergic and/or dopaminergic mechanisms. |
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Below package inserts are available for further reading:
| Document | Type | Information Source | |
|---|---|---|---|
| CONTRAVE Extended-release tablet | MPI, US: SPL/PLR | FDA, National Drug Code (US) |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC Group | Classification | |
|---|---|---|
| A08AA62 | A Alimentary tract and metabolism → A08 Antiobesity preparations, excl. diet products → A08A Antiobesity preparations, excl. diet products → A08AA Centrally acting antiobesity products | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| CA | Health Products and Food Branch | 02472945 |
| EC | Agencia Nacional de Regulación, Control y Vigilancia Sanitaria | 5906-MEE-0121 |
| HK | Department of Health Drug Office | 66934 |
| NZ | Medicines and Medical Devices Safety Authority | 20867 |
| US | FDA, National Drug Code | 43063-772, 50090-2945, 51267-890 |
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