This brand name is authorized in South Africa
The drug DALIVINE contains a combination of these active pharmaceutical ingredients (APIs):
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1
Rilpivirine
UNII 212WAX8KDD - RILPIVIRINE HYDROCHLORIDE
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Rilpivirine is a diarylpyrimidine NNRTI of HIV-1. Rilpivirine activity is mediated by non-competitive inhibition of HIV-1 reverse transcriptase (RT). Rilpivirine does not inhibit the human cellular DNA polymerases α, β and γ. |
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2
Dolutegravir
UNII 1Q1V9V5WYQ - DOLUTEGRAVIR SODIUM
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Dolutegravir inhibits HIV integrase by binding to the integrase active site and blocking the strand transfer step of retroviral Deoxyribonucleic acid (DNA) integration which is essential for the HIV replication cycle. |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| J05AR21 | Dolutegravir and rilpivirine | J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AR Antivirals for treatment of HIV infections, combinations |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: ZA | Health Products Regulatory Authority | Identifier(s): 55/20.2.8/0302.301 |
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