This brand name is authorized in Austria, Canada, Estonia, Finland, Croatia, Ireland, Lithuania, Poland, Romania, United Kingdom, United States
The drug DAURISMO contains one active pharmaceutical ingredient (API):
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Glasdegib
UNII TH2EV99S4Z - GLASDEGIB MALEATE
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Glasdegib is an inhibitor of the Hedgehog (Hh) signal transduction pathway that binds to Smoothened (SMO), a transmembrane protein, leading to decreased Glioma-Associated Oncogene (GLI) transcription factor activity and downstream pathway signalling. Hh pathway signalling is required for maintaining a leukaemic stem cell (LSC) population thus, glasdegib binding to and inhibiting SMO reduces GLI1 levels in AML cells and the leukaemic initiating potential of AML cells. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| DAURISMO Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC | |
| DAURISMO Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01XJ03 | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XJ Hedgehog pathway inhibitors | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: CA | Health Products and Food Branch | Identifier(s): 02498472, 02498480 |
| Country: EE | Ravimiamet | Identifier(s): 1821956, 1821967 |
| Country: FI | Lääkealan turvallisuus- ja kehittämiskeskus | Identifier(s): 140223, 512958 |
| Country: GB | Medicines & Healthcare Products Regulatory Agency | Identifier(s): 386990, 386995 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1090735, 1090736, 1090737, 1090738 |
| Country: PL | Rejestru Produktów Leczniczych | Identifier(s): 100439187, 100439193 |
| Country: RO | Agenția Națională a Medicamentului și a Dispozitivelor Medicale | Identifier(s): W67083001, W67083002, W67085001, W67085002 |
| Country: US | FDA, National Drug Code | Identifier(s): 0069-0298, 0069-1531 |
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