This brand name is authorized in Ecuador, New Zealand, South Africa
The drug DUOLIN contains a combination of these active pharmaceutical ingredients (APIs):
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1
Ipratropium
UNII J697UZ2A9J - IPRATROPIUM BROMIDE
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Ipratropium is a quaternary ammonium compound with anticholinergic (parasympatholytic) properties. Ipratropium appears to inhibit vagally mediated reflexes by antagonising the action of acetylcholine, the transmitter agent released from the vagus nerve. Anticholinergics prevent the increase in intracellular concentration of Ca++, which is caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle. Ca++ release is mediated by the second messenger system consisting of IP3 (inositol triphosphate) and DAG (diacylglycerol). |
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2
Salbutamol
UNII 021SEF3731 - ALBUTEROL SULFATE
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Salbutamol is a selective ฮฒ2-agonist providing short-acting (4-6 hour) bronchodilation with a fast onset (within 5 minutes) in reversible airways obstruction. At therapeutic doses it acts on the ฮฒ2-adrenoceptors of bronchial muscle. Salbutamol is administered for the symptomatic relief of bronchospasm associated with chronic or acute asthma, bronchitis or other obstructive pulmonary diseases. |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| R03AL02 | Salbutamol and ipratropium bromide | R Respiratory system → R03 Drugs for obstructive airway diseases → R03A Adrenergics, inhalants → R03AL Adrenergics in combination with anticholinergics |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: EC | Agencia Nacional de Regulaciรณn, Control y Vigilancia Sanitaria | Identifier(s): 29742-04-11 |
| Country: NZ | Medicines and Medical Devices Safety Authority | Identifier(s): 10326, 12778 |
| Country: ZA | Health Products Regulatory Authority | Identifier(s): 37/10.2.1/0012, 41/10.2.1/0908 |
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