EYLEA

This brand name is authorized in Austria, Australia, Canada, Cyprus, Estonia, Spain, Finland, France, Hong Kong, Croatia, Ireland, Israel, Japan, Lithuania, Netherlands, New Zealand, Poland, Romania, Singapore, Tunisia, Turkey, United Kingdom, United States, South Africa

Active ingredients

The drug EYLEA contains one active pharmaceutical ingredient (API):

1 Aflibercept UNII 15C2VL427D - AFLIBERCEPT

Aflibercept, also known as VEGF TRAP in the scientific literature, is a recombinant fusion protein consisting of VEGF-binding portions from the extracellular domains of human VEGF receptors 1 and 2 fused to the Fc portion of the human IgG1. Aflibercept blocks the activation of VEGF receptors and the proliferation of endothelial cells, thereby inhibiting the growth of new vessels that supply tumours with oxygen and nutrients. Read about Aflibercept

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
EYLEA 40 mg/ml Solution for injection	European Medicines Agency (EU)	MPI, EU: SmPC
EYLEA 40 mg/mL Solution for injection in pre-filled syringe	European Medicines Agency (EU)	MPI, EU: SmPC
EYLEA 114.3 mg/ml Solution for injection	European Medicines Agency (EU)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
S01LA05	Aflibercept	S Sensory organs → S01 Ophthalmologicals → S01L Ocular vascular disorder agents → S01LA Antineovascularisation agents
Discover more medicines within S01LA05

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: AU	Pharmaceutical Benefits Scheme	Identifier(s): 10505X, 11991D, 12131L, 12132M, 12141B, 12152N, 12153P, 2168D
Country: CA	Health Products and Food Branch	Identifier(s): 02415992, 02505355
Country: EE	Ravimiamet	Identifier(s): 1601457, 1601468
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 112797001, 112797002
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 145450, 532599
Country: FR	Base de données publique des médicaments	Identifier(s): 68795701, 69613703
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 216745, 381939
Country: HK	Department of Health Drug Office	Identifier(s): 61971
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 7384, 9081
Country: JP	医薬品医療機器総合機構	Identifier(s): 1319405A1027, 1319405G1020
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1068441, 1093378
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 103756
Country: NZ	Medicines and Medical Devices Safety Authority	Identifier(s): 15565
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100291098
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W63881001, W68189001
Country: SG	Health Sciences Authority	Identifier(s): 14345P, 14380P
Country: TN	Direction de la Pharmacie et du Médicament	Identifier(s): 12853081H
Country: TR	İlaç ve Tıbbi Cihaz Kurumu	Identifier(s): 8699546770052, 8699546959358
Country: US	FDA, National Drug Code	Identifier(s): 61755-005
Country: ZA	Health Products Regulatory Authority	Identifier(s): 46/15.4/0841