This brand name is authorized in France, Lithuania, United States
The drug FILSPARI contains one active pharmaceutical ingredient (API):
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1
Sparsentan
UNII 9242RO5URM - SPARSENTAN
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Sparsentan is a dual endothelin angiotensin receptor antagonist. It is a single molecule that functions as a high affinity, dual-acting antagonist of both the ETAR and AT1R. Endothelin 1, via ETAR, and angiotensin II, via AT1R, mediate processes that lead to IgAN progression through haemodynamic actions and mesangial cell proliferation, increased expression and activity of proinflammatory and profibrotic mediators, podocyte injury, and oxidative stress. Sparsentan inhibits activation of both ETAR and AT1R and thereby reduces proteinuria and slows the progression of kidney disease. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| FILSPARI Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| FILSPARI Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09XX01 | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09X Other agents acting on the renin-angiotensin system → C09XX Other agents acting on the renin-angiotensin system | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: FR | Base de données publique des médicaments | Identifier(s): 63617869, 68110738 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1099663, 1099664 |
| Country: US | FDA, National Drug Code | Identifier(s): 68974-200, 68974-400 |
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