This brand name is authorized in South Africa
The drug HAEMOSOLVEX contains a combination of these active pharmaceutical ingredients (APIs):
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1
Coagulation factor II
UNII 25ADE2236L - THROMBIN
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2
Coagulation factor IX
UNII 6U90Y1795T - COAGULATION FACTOR IX HUMAN
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Factor IX is a single chain glycoprotein with a molecular mass of about 68,000 Dalton. It is a vitamin-K dependent coagulation factor and it is synthesised in the liver. Factor IX is activated by factor XIa in the intrinsic coagulation pathway and by the factor VII/tissue factor complex in the extrinsic pathway. Activated factor IX, in combination with activated factor VIII, activates factor X. |
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3
Coagulation factor VIII
UNII 839MOZ74GK - ANTIHEMOPHILIC FACTOR HUMAN
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Activated factor VIII acts as a cofactor for activated factor IX, accelerating the conversion of factor X to activated factor X (factor Xa). Haemophilia A is a sex-linked hereditary disorder of blood coagulation due to decreased levels of factor VIII:C. By replacement therapy the plasma levels of factor VIII are increased, thereby enabling a temporary correction of the factor deficiency and correction of the bleeding tendencies. |
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4
Coagulation factor X
UNII 0P94UQE6SY - COAGULATION FACTOR X HUMAN
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Coagulation factor X is derived from human plasma and used as a replacement for the naturally existing coagulation factor X in patients with hereditary factor X deficiency. |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
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| Country: ZA | Health Products Regulatory Authority | Identifier(s): W/30.3/191 |
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