HOLOXAN

This brand name is authorized in Austria, Australia, Cyprus, Ecuador, Estonia, Finland, France, Hong Kong, Croatia, Israel, Lithuania, Netherlands, New Zealand, Poland, Romania, Singapore, Tunisia, Turkey, South Africa

Active ingredients

The drug HOLOXAN contains one active pharmaceutical ingredient (API):

1 Ifosfamide UNII UM20QQM95Y - IFOSFAMIDE

Ifosfamide is an antineoplastic, a cytotoxic alkylating agent. It is a prodrug and shows no in vitro cytotoxic activity until activated by microsomal enzymes. The cytotoxic activity of ifosfamide (alkylation of the nucleophilic centres in the cells) is associated with the activated oxazaphosphorine ring hydroxylated at the C4 atom which interacts with DNA-DNA cross linking. This activity manifests itself by blocking the late S and early G2 phases of the cell cycle. Read about Ifosfamide

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
L01AA06	Ifosfamide	L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AA Nitrogen mustard analogues
Discover more medicines within L01AA06

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: AU	Pharmaceutical Benefits Scheme	Identifier(s): 4448D, 7248L
Country: EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	Identifier(s): 28311-11-07
Country: EE	Ravimiamet	Identifier(s): 1028337, 1069028, 1069062, 1069095
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 387691, 521552, 560382
Country: FR	Base de données publique des médicaments	Identifier(s): 61848140, 69622218
Country: HK	Department of Health Drug Office	Identifier(s): 01322
Country: HR	Agencija za lijekove i medicinske proizvode	Identifier(s): HR-H-366159114, HR-H-792917744
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 8007
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1003998, 1003999
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 14796, 14818, 14826
Country: NZ	Medicines and Medical Devices Safety Authority	Identifier(s): 4977, 4982, 4983
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100029271, 100029288
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W12497001, W12497002
Country: SG	Health Sciences Authority	Identifier(s): 01699P
Country: TN	Direction de la Pharmacie et du Médicament	Identifier(s): 2613011H, 2613012H, 2613013H
Country: TR	İlaç ve Tıbbi Cihaz Kurumu	Identifier(s): 8681413881077, 8681413881084, 8681413881091
Country: ZA	Health Products Regulatory Authority	Identifier(s): K/26/31, K/26/32, K/26/33, K/26/34