HOLOXAN

This brand name is authorized in Australia, Austria, Croatia, Cyprus, Ecuador, Estonia, Finland, France, Hong Kong SAR China, Israel, Lithuania, Netherlands, New Zealand, Poland, Romania, Singapore, South Africa, Tunisia, Turkey.

Active ingredients

The drug HOLOXAN contains one active pharmaceutical ingredient (API):

1	Ifosfamide UNII UM20QQM95Y - IFOSFAMIDE
	Ifosfamide is an antineoplastic, a cytotoxic alkylating agent. It is a prodrug and shows no in vitro cytotoxic activity until activated by microsomal enzymes. The cytotoxic activity of ifosfamide (alkylation of the nucleophilic centres in the cells) is associated with the activated oxazaphosphorine ring hydroxylated at the C4 atom which interacts with DNA-DNA cross linking. This activity manifests itself by blocking the late S and early G2 phases of the cell cycle.
	Read more about Ifosfamide

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC Group		Classification
L01AA06	Ifosfamide	L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AA Nitrogen mustard analogues
Discover more medicines within L01AA06

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
AU	Pharmaceutical Benefits Scheme	4448D, 7248L
EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	28311-11-07
EE	Ravimiamet	1028337, 1069028, 1069062, 1069095
FI	Lääkealan turvallisuus- ja kehittämiskeskus	387691, 521552, 560382
FR	Base de données publique des médicaments	61848140, 69622218
HK	Department of Health Drug Office	01322
HR	Agencija za lijekove i medicinske proizvode	HR-H-366159114, HR-H-792917744
IL	מִשְׂרַד הַבְּרִיאוּת	8007
LT	Valstybinė vaistų kontrolės tarnyba	1003998, 1003999
NL	Z-Index G-Standaard, PRK	14796, 14818, 14826
NZ	Medicines and Medical Devices Safety Authority	4977, 4982, 4983
PL	Rejestru Produktów Leczniczych	100029271, 100029288
RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	W12497001, W12497002
SG	Health Sciences Authority	01699P
TN	Direction de la Pharmacie et du Médicament	2613011H, 2613012H, 2613013H
TR	İlaç ve Tıbbi Cihaz Kurumu	8681413881077, 8681413881084, 8681413881091
ZA	Health Products Regulatory Authority	K/26/31, K/26/32, K/26/33, K/26/34