JAKAVI

This brand name is authorized in Austria, Australia, Brazil, Canada, Cyprus, Ecuador, Estonia, Spain, Finland, France, Hong Kong, Croatia, Ireland, Israel, Japan, Lithuania, Netherlands, New Zealand, Poland, Romania, Singapore, Tunisia, Turkey, United Kingdom, South Africa

Active ingredients

The drug JAKAVI contains one active pharmaceutical ingredient (API):

1 Ruxolitinib UNII 436LRU32H5 - RUXOLITINIB PHOSPHATE

Ruxolitinib is a selective inhibitor of the Janus Associated Kinases (JAKs) JAK1 and JAK2 (IC50 values of 3.3 nM and 2.8 nM for JAK1 and JAK2 enzymes, respectively). These mediate the signalling of a number of cytokines and growth factors that are important for haematopoiesis and immune function. Ruxolitinib inhibits cytokine-induced STAT3 phosphorylation in whole blood from healthy subjects, MF patients and PV patients. Read about Ruxolitinib

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
JAKAVI Tablet	European Medicines Agency (EU)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
L01EJ01	Ruxolitinib	L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EJ Janus-associated kinase (JAK) inhibitors
Discover more medicines within L01EJ01

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: AU	Pharmaceutical Benefits Scheme	Identifier(s): 10614P, 10615Q, 10616R, 10617T, 10618W, 10619X, 10913J, 10927D
Country: BR	Câmara de Regulação do Mercado de Medicamentos	Identifier(s): 526516020085601, 526516020085701, 526516020085801, 526520070095707
Country: CA	Health Products and Food Branch	Identifier(s): 02388006, 02388014, 02388022, 02434814
Country: EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	Identifier(s): 1130-MEE-0715, H45110513, H45130513, H5120513
Country: EE	Ravimiamet	Identifier(s): 1593020, 1593042, 1593053, 1632800, 1632877, 1632888, 1632899, 1632901, 1632912, 1632923, 1632934, 1632945, 1666010, 1666021, 1666032, 1666043
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 112773005, 112773008, 112773011, 112773015
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 106390, 461113, 488468, 553720
Country: FR	Base de données publique des médicaments	Identifier(s): 60672974, 65291824, 65584250, 66180136
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 229518, 229748, 229750, 295076
Country: HK	Department of Health Drug Office	Identifier(s): 61972, 61973, 61974, 66148
Country: IE	Health Products Regulatory Authority	Identifier(s): 88170, 88182, 88279, 88289
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 7170, 7171, 7172, 8088
Country: JP	医薬品医療機器総合機構	Identifier(s): 4291034F1029, 4291034F2025
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1071542, 1071543, 1071544, 1071545, 1071546, 1071547, 1071548, 1071549, 1071550, 1076654, 1076655, 1076656
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 108464, 108472, 108480, 150843
Country: NZ	Medicines and Medical Devices Safety Authority	Identifier(s): 16260, 16261, 16262, 19243
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100283673, 100283680, 100283696, 100329688
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W64593001, W64594001, W64595001, W64596001
Country: SG	Health Sciences Authority	Identifier(s): 14396P, 14397P, 14398P, 14927P
Country: TN	Direction de la Pharmacie et du Médicament	Identifier(s): 10283361H, 10283362H, 10283363H
Country: TR	İlaç ve Tıbbi Cihaz Kurumu	Identifier(s): 8699504012231, 8699504012248, 8699504012255, 8699504012262, 8699504013177, 8699504013184, 8699504013191, 8699504013207, 8699504013214, 8699504013221, 8699504013238
Country: ZA	Health Products Regulatory Authority	Identifier(s): 48/34/0109, 48/34/0110, 48/34/0111