KEVZARA

This brand name is authorized in United States. It is also authorized in Austria, Canada, Croatia, Estonia, Finland, France, Hong Kong SAR China, Ireland, Israel, Italy, Japan, Lithuania, Netherlands, Poland, Singapore, Spain, UK.

Active ingredients

The drug KEVZARA contains one active pharmaceutical ingredient (API):

1	Sarilumab UNII NU90V55F8I - SARILUMAB
	Sarilumab is a human monoclonal antibody (IgG1 subtype) that specifically binds to both soluble and membrane-bound IL-6 receptors (IL-6Rα), and inhibits IL-6-mediated signalling which involves ubiquitous signal-transducing glycoprotein 130 (gp130) and the Signal Transducer and Activator of Transcription-3 (STAT-3). In functional human cell-based assays, sarilumab was able to block the IL-6 signalling pathway, measured as STAT-3 inhibition, only in the presence of IL-6.
	Read more about Sarilumab

Medication package inserts

Below package inserts are available for further reading:

Document	Type	Information Source
KEVZARA 150 mg / 200 mg Solution for injection	MPI, EU: SmPC	European Medicines Agency (EU)
KEVZARA 175 mg/ml Solution for injection	MPI, EU: SmPC	European Medicines Agency (EU)

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC Group		Classification
L04AC14		L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AC Interleukin inhibitors
Discover more medicines within L04AC14

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
CA	Health Products and Food Branch	02460521, 02460548, 02472961, 02472988
EE	Ravimiamet	1748583, 1748594, 1748606, 1748617, 1748628, 1748639, 1748640, 1748651, 1786945, 1786956, 1786967, 1786978
ES	Centro de información online de medicamentos de la AEMPS	1171196003, 1171196005, 1171196007
FI	Lääkealan turvallisuus- ja kehittämiskeskus	479260, 545229, 576613
FR	Base de données publique des médicaments	61709735, 63820638, 64326560, 69240179
GB	Medicines & Healthcare Products Regulatory Agency	347354, 347357, 347360, 347363
HK	Department of Health Drug Office	65726, 65727
IL	מִשְׂרַד הַבְּרִיאוּת	8118, 8119
IT	Agenzia del Farmaco	045491014, 045491026, 045491038, 045491040, 045491053, 045491065, 045491077, 045491089, 045491091, 045491103, 045491115, 045491127
JP	医薬品医療機器総合機構	3999444G1022, 3999444G2029, 3999444G3025, 3999444G4021
LT	Valstybinė vaistų kontrolės tarnyba	1083200, 1083201, 1083202, 1083203, 1083204, 1083205, 1083206, 1083207, 1084576, 1084577, 1084578, 1084579
NL	Z-Index G-Standaard, PRK	144177, 144185, 144215, 144223
PL	Rejestru Produktów Leczniczych	100390593, 100390601, 100390618, 100390624
SG	Health Sciences Authority	15681P, 15682P, 15737P, 15738P
US	FDA, National Drug Code	0024-5908, 0024-5910, 0024-5920, 0024-5922