MALARONE

This brand name is authorized in United States. It is also authorized in Australia, Austria, Canada, Estonia, Finland, France, Ireland, Israel, Japan, Lithuania, Malta, Netherlands, New Zealand, Poland, Singapore, Spain, UK.

Active ingredients

The drug MALARONE contains a combination of these active pharmaceutical ingredients (APIs):

1	Atovaquone UNII Y883P1Z2LT - ATOVAQUONE
	Atovaquone is a selective and potent inhibitor of the eukaryotic mitochondrial electron transport chain in a number of parasitic protozoa and the parasitic fungus P. jiroveci. The site of action appears to be the cytochrome bc1 complex (complex III).
	Read more about Atovaquone
2	Proguanil UNII R71Y86M0WT - PROGUANIL HYDROCHLORIDE
	Proguanil is an antimalarial drug and dihydrofolate reductase inhibitor. It acts like the other antifolate antimalarials by interfering with the folic-folinic acid systems and thus exerts its effect mainly at the time the nucleus is dividing. Proguanil is effective against the exoerythrocytic forms of some strains of plasmodium falciparum but it has little or no activity against the exoerythrocytic forms of p. Vivax.
	Read more about Proguanil

Medication package inserts

Below package inserts are available for further reading:

Document	Type	Information Source
MALARONE Film-coated tablet	MPI, EU: SmPC	Medicines & Healthcare Products Regulatory Agency (GB)
MALARONE PAEDIATRIC Film-coated tablet	MPI, EU: SmPC	Medicines & Healthcare Products Regulatory Agency (GB)

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC Group		Classification
P01BB51	Proguanil and atovaquone	P Antiparasitic products, insecticides and repellents → P01 Antiprotozoals → P01B Antimalarials → P01BB Biguanides
Discover more medicines within P01BB51

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
AU	Pharmaceutical Benefits Scheme	9439T
CA	Health Products and Food Branch	02238151, 02264935
EE	Ravimiamet	1129968, 1129979, 1873436, 1873447
ES	Centro de información online de medicamentos de la AEMPS	63452, 65257
FI	Lääkealan turvallisuus- ja kehittämiskeskus	477059
FR	Base de données publique des médicaments	60981593, 61638010
GB	Medicines & Healthcare Products Regulatory Agency	196961, 36325, 36391, 373893, 376740, 381481
IE	Health Products Regulatory Authority	32590
IL	מִשְׂרַד הַבְּרִיאוּת	4647, 4648
JP	医薬品医療機器総合機構	6419101F1020, 6419101F2026
LT	Valstybinė vaistų kontrolės tarnyba	1021215, 1087922, 1089021, 1091522
MT	Medicines Authority	MA192/04401, PI1438/09201A, PI908/14001A
NL	Z-Index G-Standaard, PRK	54771, 69132
NZ	Medicines and Medical Devices Safety Authority	10697, 9021
PL	Rejestru Produktów Leczniczych	100160195, 100330415, 100353280, 100377061, 100382560, 100384658, 100392540, 100396354, 100416660, 100419463, 100429384
SG	Health Sciences Authority	09761P
US	FDA, National Drug Code	0173-0675, 0173-0676, 50090-0687, 55289-747