MALARONE

This brand name is authorized in Austria, Australia, Canada, Estonia, Spain, Finland, France, Ireland, Israel, Japan, Lithuania, Malta, Netherlands, New Zealand, Poland, Singapore, United Kingdom, United States

Active ingredients

The drug MALARONE contains a combination of these active pharmaceutical ingredients (APIs):

1 Atovaquone UNII Y883P1Z2LT - ATOVAQUONE

Atovaquone is a selective and potent inhibitor of the eukaryotic mitochondrial electron transport chain in a number of parasitic protozoa and the parasitic fungus P. jiroveci. The site of action appears to be the cytochrome bc1 complex (complex III). Read about Atovaquone

2 Proguanil UNII R71Y86M0WT - PROGUANIL HYDROCHLORIDE

Proguanil is an antimalarial drug and dihydrofolate reductase inhibitor. It acts like the other antifolate antimalarials by interfering with the folic-folinic acid systems and thus exerts its effect mainly at the time the nucleus is dividing. Proguanil is effective against the exoerythrocytic forms of some strains of plasmodium falciparum but it has little or no activity against the exoerythrocytic forms of p. Vivax. Read about Proguanil

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
MALARONE Film-coated tablet	Medicines & Healthcare Products Regulatory Agency (GB)	MPI, EU: SmPC
MALARONE PAEDIATRIC Film-coated tablet	Medicines & Healthcare Products Regulatory Agency (GB)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
P01BB51	Proguanil and atovaquone	P Antiparasitic products, insecticides and repellents → P01 Antiprotozoals → P01B Antimalarials → P01BB Biguanides
Discover more medicines within P01BB51

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: AU	Pharmaceutical Benefits Scheme	Identifier(s): 9439T
Country: CA	Health Products and Food Branch	Identifier(s): 02238151, 02264935
Country: EE	Ravimiamet	Identifier(s): 1129968, 1129979, 1873436, 1873447
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 63452, 65257
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 477059
Country: FR	Base de données publique des médicaments	Identifier(s): 60981593, 61638010
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 196961, 36325, 36391, 373893, 376740, 381481
Country: IE	Health Products Regulatory Authority	Identifier(s): 32590
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 4647, 4648
Country: JP	医薬品医療機器総合機構	Identifier(s): 6419101F1020, 6419101F2026
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1021215, 1087922, 1089021, 1091522
Country: MT	Medicines Authority	Identifier(s): MA192/04401, PI1438/09201A, PI908/14001A
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 54771, 69132
Country: NZ	Medicines and Medical Devices Safety Authority	Identifier(s): 10697, 9021
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100160195, 100330415, 100353280, 100377061, 100382560, 100384658, 100392540, 100396354, 100416660, 100419463, 100429384
Country: SG	Health Sciences Authority	Identifier(s): 09761P
Country: US	FDA, National Drug Code	Identifier(s): 0173-0675, 0173-0676, 50090-0687, 55289-747