MEKINIST

This brand name is authorized in Austria, Australia, Brazil, Canada, Cyprus, Ecuador, Estonia, Spain, Finland, France, Hong Kong, Croatia, Ireland, Israel, Italy, Japan, Lithuania, Netherlands, New Zealand, Poland, Romania, Singapore, Turkey, United Kingdom, United States, South Africa

Active ingredients

The drug MEKINIST contains one active pharmaceutical ingredient (API):

1 Trametinib UNII BSB9VJ5TUT - TRAMETINIB DIMETHYL SULFOXIDE

Trametinib is a reversible, highly selective, allosteric inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activation and kinase activity. In melanoma and other cancers, this pathway is often activated by mutated forms of BRAF which activates MEK. Trametinib inhibits activation of MEK by BRAF and inhibits MEK kinase activity. Read about Trametinib

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
MEKINIST Film-coated tablet	European Medicines Agency (EU)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
L01EE01		L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EE Mitogen-activated protein kinase (MEK) inhibitors
Discover more medicines within L01EE01

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: AU	Pharmaceutical Benefits Scheme	Identifier(s): 10382K, 10385N, 10403M, 10405P, 11819C, 11821E
Country: BR	Câmara de Regulação do Mercado de Medicamentos	Identifier(s): 526517030088202, 526517030088302
Country: CA	Health Products and Food Branch	Identifier(s): 02409623, 02409658
Country: EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	Identifier(s): 2334-MEE-0716, 2401-MEE-0816
Country: EE	Ravimiamet	Identifier(s): 1656930, 1656941, 1656952, 1656963, 1656974, 1656985
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 114931002, 114931006
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 178273, 374194
Country: FR	Base de données publique des médicaments	Identifier(s): 61803451, 62348191
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 310793, 310794, 310799, 310800, 368156, 383739
Country: HK	Department of Health Drug Office	Identifier(s): 64520, 64521
Country: IE	Health Products Regulatory Authority	Identifier(s): 88886, 88887
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 7826, 7848
Country: IT	Agenzia del Farmaco	Identifier(s): 043524014, 043524026, 043524038, 043524040, 043524053, 043524065
Country: JP	医薬品医療機器総合機構	Identifier(s): 4291047F1026, 4291047F2022
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1073770, 1073771, 1073772, 1073773, 1073774, 1073775
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 127884, 127892
Country: NZ	Medicines and Medical Devices Safety Authority	Identifier(s): 16550, 16552
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100317573, 100317596
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W64448001, W64448002, W64449001, W64449002
Country: SG	Health Sciences Authority	Identifier(s): 15181P, 15182P
Country: TR	İlaç ve Tıbbi Cihaz Kurumu	Identifier(s): 8699504092196, 8699504092202, 8699504092226, 8699504092233
Country: US	FDA, National Drug Code	Identifier(s): 0078-0666, 0078-0668, 0078-1105, 0078-1112, 0078-1161
Country: ZA	Health Products Regulatory Authority	Identifier(s): 51/32.2/0820