NARIDRIN

This brand name is authorized in Brazil.

Active ingredients

The drug NARIDRIN contains a combination of these active pharmaceutical ingredients (APIs):

1
UNII MZ1131787D - NAPHAZOLINE HYDROCHLORIDE
 

Naphazoline is a sympathomimetic amine with pronounced alpha adrenergic activity and as a consequence has vasoconstrictor activity.

 
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2
UNII 1O6C93RI7Z - DEXPANTHENOL
 

Dexpanthenol is converted in tissues to pantothenic acid, a component of coenzyme A (CoA) that is essential to normal epithelial function, increased fibroblast proliferation and accelerated re-epithelialization in wound healing.

 
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3
UNII R35D29L3ZA - PYRILAMINE MALEATE
 

Mepyramine is a first generation antihistamine, targeting the H1 receptor. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. Mepyramine is a histamine H1 receptor inverse agonist. It binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Mepyramine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of mepyramine occur at the subcortical level of the CNS. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.

 
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Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
BR Câmara de Regulação do Mercado de Medicamentos 507718101171416, 507718102176411, 507718103172411

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