This brand name is authorized in Austria, Croatia, Estonia, Ireland, Italy, Lithuania, Poland, Turkey, UK.
The drug NUSTENDI contains a combination of these active pharmaceutical ingredients (APIs):
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UNII
1EJ6Z6Q368 - BEMPEDOIC ACID
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Bempedoic acid is an adenosine triphosphate citrate lyase (ACL) inhibitor that lowers low-density lipoprotein cholesterol (LDL-C) by inhibition of cholesterol synthesis in the liver. Bempedoic acid requires coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1) to ETC-1002-CoA. Inhibition of ACL by ETC-1002-CoA results in decreased cholesterol synthesis in the liver and lowers LDL-C in blood via upregulation of low-density lipoprotein receptors. Additionally, inhibition of ACL by ETC-1002-CoA results in concomitant suppression of hepatic fatty acid biosynthesis. |
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EOR26LQQ24 - EZETIMIBE
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Ezetimibe is in a new class of lipid-lowering compounds that selectively inhibit the intestinal absorption of cholesterol. The molecular target of ezetimibe is the sterol transporter, Niemann-Pick C1-Like 1 (NPC1L1), which is responsible for the intestinal uptake of cholesterol. |
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This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC Group | Classification | |
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| C10BA10 | C Cardiovascular system → C10 Lipid modifying agents → C10B Lipid modifying agents, combinations → C10BA Combinations of various lipid modifying agents | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| EE | Ravimiamet | 1816141, 1816152, 1816163, 1816174, 1816185, 1816196 |
| GB | Medicines & Healthcare Products Regulatory Agency | 387552 |
| IT | Agenzia del Farmaco | 048668014, 048668026, 048668038, 048668040, 048668053, 048668065, 048668077, 048668089, 048668091, 048668103, 048668115 |
| LT | Valstybinė vaistų kontrolės tarnyba | 1089812, 1089813, 1089814, 1089815, 1089816, 1089817, 1091052, 1091053, 1091054, 1091055, 1091057 |
| PL | Rejestru Produktów Leczniczych | 100392333 |
| TR | İlaç ve Tıbbi Cihaz Kurumu | 8699228090843, 8699228090850, 8699228090867, 8699228090874, 8699228090881 |
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