ONPATTRO

This brand name is authorized in United States. It is also authorized in Austria, Brazil, Canada, Croatia, Cyprus, Estonia, France, Ireland, Israel, Italy, Japan, Lithuania, Netherlands, Poland, Romania, Spain, UK.

Active ingredients

The drug ONPATTRO contains one active pharmaceutical ingredient (API):

1	Patisiran UNII WO0YM16LKG - PATISIRAN SODIUM
	Patisiran is a double-stranded small interfering ribonucleic acid (siRNA) that specifically targets a genetically conserved sequence in the 3’ untranslated region of all mutant and wild-type TTR mRNA. Through a natural process called RNA interference (RNAi), patisiran causes the catalytic degradation of TTR mRNA in the liver, resulting in a reduction of serum TTR protein, a carrier of retinol binding protein which facilitates transport of vitamin A in the blood.
	Read more about Patisiran

Medication package inserts

Below package inserts are available for further reading:

Document	Type	Information Source
ONPATTRO Concentrate for solution for infusion	MPI, EU: SmPC	European Medicines Agency (EU)

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC Group		Classification
N07XX12		N Nervous system → N07 Other nervous system drugs → N07X Other nervous system drugs → N07XX Other nervous system drugs
Discover more medicines within N07XX12

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
BR	Câmara de Regulação do Mercado de Medicamentos	587920070000107
CA	Health Products and Food Branch	02489252
EE	Ravimiamet	1779004
ES	Centro de información online de medicamentos de la AEMPS	1181320001
FR	Base de données publique des médicaments	62111751
GB	Medicines & Healthcare Products Regulatory Agency	374981
IL	מִשְׂרַד הַבְּרִיאוּת	8522
IT	Agenzia del Farmaco	046993010
JP	医薬品医療機器総合機構	1290400A1024
LT	Valstybinė vaistų kontrolės tarnyba	1086213
NL	Z-Index G-Standaard, PRK	196010
PL	Rejestru Produktów Leczniczych	100410723
RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	W64892001
US	FDA, National Drug Code	71336-1000