This brand name is authorized in Brazil, Spain, France, Japan, New Zealand
The drug POLARAMINE contains one active pharmaceutical ingredient (API):
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1
Dexchlorpheniramine
UNII B10YD955QW - DEXCHLORPHENIRAMINE MALEATE
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Dexchlorpheniramine, the d-isomer of the racemic compound chlorpheniramine, is two times more active than chlorpheniramine. Dexchlorpheniramine does not prevent the release of histamine, but rather, competes with free histamine for binding at the H1-receptor sites, and competitively antagonizes the effects of histamine on H1-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Blockade of H1-receptors also suppresses the formation of oedema, flare, and pruritus that result from histaminic activity. Since dexchlorpheniramine binds to central and peripheral H1-receptors, sedative effects are likely to occur. Dexchlorpheniramine has high antihistaminic activity, moderate anticholinergic effects and minimal sedative effects. |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| R06AB02 | Dexchlorpheniramine | R Respiratory system → R06 Antihistamines for systemic use → R06A Antihistamines for systemic use → R06AB Substituted alkylamines |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: BR | Câmara de Regulação do Mercado de Medicamentos | Identifier(s): 540916090022017, 540916090022117, 540916090022217, 540916090022317, 540916090022417 |
| Country: ES | Centro de información online de medicamentos de la AEMPS | Identifier(s): 31195, 32801, 40135 |
| Country: FR | Base de données publique des médicaments | Identifier(s): 65227405, 65570749 |
| Country: JP | 医薬品医療機器総合機構 | Identifier(s): 4419002B1033, 4419002F1027, 4419002Q1095, 4419002R1031, 4419400A1023 |
| Country: NZ | Medicines and Medical Devices Safety Authority | Identifier(s): 13148, 2163 |
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