RETSEVMO

This brand name is authorized in Austria, Estonia, Spain, Finland, France, Croatia, Ireland, Italy, Lithuania, Poland, Romania, United Kingdom

Active ingredients

The drug RETSEVMO contains one active pharmaceutical ingredient (API):

1 Selpercatinib UNII CEGM9YBNGD - SELPERCATINIB

Selpercatinib is an inhibitor of the rearranged during transfection (RET) receptor tyrosine kinase. Selpercatinib inhibited wild-type RET and multiple mutated RET isoforms as well as VEGFR1 and VEGFR3 with IC50 values ranging from 0.92 nM to 67.8 nM. In in vitro and in vivo tumor models, selpercatinib demonstrated anti-tumor activity in cells harboring constitutive activation of RET protein resulting from gene fusions and mutations, including CCDC6-RET, KIF5B-RET, RET V804M, and RET M918T. Read about Selpercatinib

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
RETSEVMO Hard capsule	European Medicines Agency (EU)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
L01EX22		L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EX Other protein kinase inhibitors
Discover more medicines within L01EX22

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: EE	Ravimiamet	Identifier(s): 1842511, 1842522, 1842533
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 1201527001, 1201527002
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 451289, 452618, 464989, 495704
Country: FR	Base de données publique des médicaments	Identifier(s): 61648467, 66580529
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 394207, 394210
Country: IT	Agenzia del Farmaco	Identifier(s): 049358017, 049358029, 049358031, 049358043, 049358056, 049358068, 049358070, 049358082, 049358094, 049358106, 049358118
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1092128, 1092129, 1092130, 1092963, 1092964, 1092965, 1092966, 1092967, 1092968, 1092969, 1092970
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100448387, 100448393
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W67513001, W67513002, W67514001, W67514002, W67514003