TALZENNA

This brand name is authorized in Austria, Ecuador, Estonia, France, Hong Kong, Croatia, Ireland, Israel, Italy, Lithuania, Nigeria, Netherlands, Poland, Romania, Turkey, United Kingdom, United States

Active ingredients

The drug TALZENNA contains one active pharmaceutical ingredient (API):

1 Talazoparib UNII 02WK9U5NZC - TALAZOPARIB TOSYLATE

Talazoparib is an inhibitor of PARP enzymes, PARP1, and PARP2. PARP enzymes are involved in cellular DNA damage response signalling pathways such as DNA repair, gene transcription, and cell death. PARP inhibitors (PARPi) exert cytotoxic effects on cancer cells by 2 mechanisms, inhibition of PARP catalytic activity and by PARP trapping, whereby PARP protein bound to a PARPi does not readily dissociate from a DNA lesion, thus preventing DNA repair, replication, and transcription, thereby resulting in apoptosis and/or cell death. Read about Talazoparib

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
TALZENNA Hard capsule	European Medicines Agency (EU)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
L01XK04		L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XK Poly (ADP-ribose) polymerase (PARP) inhibitors
Discover more medicines within L01XK04

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	Identifier(s): 6233-MEE-0521, 6553-MEE-0821
Country: EE	Ravimiamet	Identifier(s): 1798623, 1798634, 1798645, 1798656
Country: FR	Base de données publique des médicaments	Identifier(s): 61710730, 62184233, 65301389
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 376499, 376508
Country: HK	Department of Health Drug Office	Identifier(s): 66589, 66590
Country: IE	Health Products Regulatory Authority	Identifier(s): 89076, 89077
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 8544, 8545
Country: IT	Agenzia del Farmaco	Identifier(s): 048057018, 048057020, 048057032, 048057044, 048057057, 048057069
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1088121, 1088122, 1088123, 1088124, 1088125, 1088126
Country: NG	Registered Drug Product Database	Identifier(s): A4-100089, A4-100090
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 201820, 201839
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100423387, 100423393
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W66678001, W66678002, W66678003, W66678004, W66679001, W66679002
Country: TR	İlaç ve Tıbbi Cihaz Kurumu	Identifier(s): 8681308151100, 8681308151117
Country: US	FDA, National Drug Code	Identifier(s): 0069-0296, 0069-1195, 63539-295