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Potassium iodide is indicated as a thyroid-blocking agent to prevent the uptake of radioactive iodine, for example after a nuclear accident or during a nuclear medicine investigation before administering a radioiodinated compound, which is metabolised to iodide or which contains radioiodine impurities.

Iodine is an essential trace element in the human diet, necessary for the formation of thyroid hormones and consequently it is used in iodine deficiency and thyroid disorders. It also has antimicrobial activity.

For the prophylaxis and treatment of iodine deficiency disorders it may be given as potassium or sodium iodide, iodised oil, or potassium iodate. In the pre-operative management of hyperthyroidism iodine and iodides are used with antithyroid drugs such as carbimazole, thiamazole, or propylthiouracil.

Iodine has a powerful bactericidal action. It is also active against fungi, viruses, protozoa, cysts, and spores. Iodine is used as an antiseptic and disinfectant generally as a 2% or 2.5% solution.