This brand name is authorized in Austria, Cyprus, Estonia, Finland, Ireland, Lithuania, Netherlands, Poland, Romania, UK.
The drug TEYSUNO contains a combination of these active pharmaceutical ingredients (APIs):
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UNII
1548R74NSZ - TEGAFUR
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Tegafur is a prodrug of 5-FU with good oral bioavailability. Following oral administration, tegafur is gradually converted to 5-FU in vivo, mainly by CYP2A6 enzyme activity in the liver. 5-FU is metabolised by the liver enzyme DPD. 5-FU is activated within cells by phosphorylation to its active metabolite, 5-fluoro-deoxyuridine-monophosphate (FdUMP). FdUMP and reduced folate are bound to thymidylate synthase leading to formation of a ternary complex which inhibits DNA synthesis. In addition, 5-fluorouridine-triphosphate (FUTP) is incorporated into RNA causing disruption of RNA functions. |
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This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC Group | Classification | |
|---|---|---|
| L01BC53 | Tegafur, combinations | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BC Pyrimidine analogues |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| EE | Ravimiamet | 1523832, 1523843, 1523854, 1523865, 1598205 |
| FI | Lääkealan turvallisuus- ja kehittämiskeskus | 134175, 185610, 482719, 582618 |
| GB | Medicines & Healthcare Products Regulatory Agency | 203667, 203672 |
| IE | Health Products Regulatory Authority | 88328, 88329 |
| LT | Valstybinė vaistų kontrolės tarnyba | 1059833, 1059834, 1059835, 1059836, 1068424 |
| NL | Z-Index G-Standaard, PRK | 102881, 102903 |
| PL | Rejestru Produktów Leczniczych | 100353379, 100353391 |
| RO | Agenția Națională a Medicamentului și a Dispozitivelor Medicale | W58736001, W58736002, W58737001, W58737002 |
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