TOPSITON

This brand name is authorized in South Africa

Active ingredients

The drug TOPSITON contains a combination of these active pharmaceutical ingredients (APIs):

1 Calcium citrate
UNII MLM29U2X85 - CALCIUM CITRATE

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium.

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2 Calcium gluconate
UNII SQE6VB453K - CALCIUM GLUCONATE

Calcium gluconate is the gluconate salt of calcium. An element or mineral necessary for normal nerve, muscle, and cardiac function, calcium as the gluconate salt helps to maintain calcium balance and prevent bone loss when taken orally.

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3 Dexpanthenol
UNII 1O6C93RI7Z - DEXPANTHENOL

Dexpanthenol is converted in tissues to pantothenic acid, a component of coenzyme A (CoA) that is essential to normal epithelial function, increased fibroblast proliferation and accelerated re-epithelialization in wound healing.

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4 Niacinamide
UNII 2679MF687A - NIACIN
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5 Riboflavine sodium phosphate
UNII 04SRR95RP8 - RIBOFLAVIN SODIUM

Riboflavine is phosphorylated to flavine mononucleotide and flavine adenine dinucleotide which act as co-enzymes in the respiratory chain and in oxidative phosphorylation. Riboflavine deficiency presents with ocular symptoms, as well as lesions on the lips and at angles of the mouth.

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6 Vitamin B1
UNII M572600E5P - THIAMINE HYDROCHLORIDE

Thiamine pyrophosphate (TPP), the coenzymatic form of thiamine, is involved in two main types of metabolic reactions: decarboxylation of α-ketoacids (e.g. pyruvate, α-ketoglutarate and branched-chain keto acids) and transketolation (e.g. among hexose and pentose phosphates). Therefore, the principal physiological role of thiamine is as a coenzyme in carbohydrate metabolism, where TPP is required for several stages in the breakdown of glucose to provide energy.

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7 Caffeine
UNII 3G6A5W338E - CAFFEINE

Caffeine is structurally related to the methylxanthines theophylline and theobromine. Caffeine’s main action is as a CNS stimulant.

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Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: ZA Health Products Regulatory Authority Identifier(s): Q/33/25

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