TORISEL

This brand name is authorized in Austria, Brazil, Canada, Cyprus, Estonia, Spain, Finland, France, Croatia, Ireland, Israel, Italy, Japan, Lithuania, Netherlands, Poland, Romania, Singapore, Turkey, United Kingdom, South Africa

Active ingredients

The drug TORISEL contains one active pharmaceutical ingredient (API):

1 Temsirolimus UNII 624KN6GM2T - TEMSIROLIMUS

Temsirolimus is a selective inhibitor of mTOR (mammalian target of rapamycin). Temsirolimus binds to an intracellular protein (FKBP-12), and the protein/temsirolimus complex binds and inhibits the activity of mTOR that controls cell division. In vitro, at high concentrations (10-20 M), temsirolimus can bind and inhibit mTOR in the absence of FKBP-12. When mTOR activity is inhibited, its ability to phosphorylate, and thereby control the activity of protein translation factors (4E-BP1 and S6K, both downstream of mTOR in the P13 kinase/AKT pathway) that control cell division, is blocked. Read about Temsirolimus

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
TORISEL Concentrate and solvent for solution for infusion	European Medicines Agency (EU)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
L01EG01	Temsirolimus	L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EG Mammalian target of rapamycin (mTOR) kinase inhibitors
Discover more medicines within L01EG01

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: BR	Câmara de Regulação do Mercado de Medicamentos	Identifier(s): 522720050087217
Country: CA	Health Products and Food Branch	Identifier(s): 02304104
Country: EE	Ravimiamet	Identifier(s): 1342303
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 07424001
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 061715
Country: FR	Base de données publique des médicaments	Identifier(s): 60443413
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 146030
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 6993
Country: IT	Agenzia del Farmaco	Identifier(s): 038327019
Country: JP	医薬品医療機器総合機構	Identifier(s): 4291418A1025
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1031298
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 85022
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100181790
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W64785001
Country: SG	Health Sciences Authority	Identifier(s): 13729P
Country: TR	İlaç ve Tıbbi Cihaz Kurumu	Identifier(s): 8681308777621
Country: ZA	Health Products Regulatory Authority	Identifier(s): 42/26/0227