This brand name is authorized in Estonia, Spain, Croatia, Lithuania, Malta, Poland, Romania
The drug TRESUVI contains one active pharmaceutical ingredient (API):
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1
Treprostinil
UNII 7JZ75N2NT6 - TREPROSTINIL SODIUM
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Treprostinil is a vasodilator that is used for the treatment of pulmonary arterial hypertension. Treprostinil is a potent oral antiplatelet agent. The major pharmacologic actions of treprostinil are direct vasodilation of pulmonary and systemic arterial vascular beds and inhibition of platelet aggregation. Other studies have shown that treprostinil causes a dose-related negative inotropic and lusitropic effect. Treprostinil had high affinity for the Prostaglandin D2 receptor (DP1), Prostaglandin E2 receptor EP2 subtype (EP2) and Prostaglandin D2 receptor (IP) receptors (Ki 4.4, 3.6 and 32 nM, respectively), low affinity for EP1 and EP4 receptors and even lower affinity for EP3, Prostaglandin F (FP) and thromboxane (TP) receptors. Treprostinil has demonstrated a unique effect on PPAR gamma, a transcription factor important in vascular pathogenesis as a mediator of proliferation, inflammation and apoptosis. |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| B01AC21 | Treprostinil | B Blood and blood forming organs → B01 Antithrombotic agents → B01A Antithrombotic agents → B01AC Platelet aggregation inhibitors excl. heparin |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: EE | Ravimiamet | Identifier(s): 1803798, 1803800, 1803811, 1803822 |
| Country: ES | Centro de información online de medicamentos de la AEMPS | Identifier(s): 84771, 84772, 84773, 84774 |
| Country: HR | Agencija za lijekove i medicinske proizvode | Identifier(s): HR-H-579967087, HR-H-745171074, HR-H-777980453, HR-H-816101187 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1092043, 1092044, 1092045, 1092046 |
| Country: MT | Medicines Authority | Identifier(s): MA1167/00201, MA1167/00202, MA1167/00203, MA1167/00204 |
| Country: PL | Rejestru Produktów Leczniczych | Identifier(s): 100423625, 100423631, 100423648, 100423654 |
| Country: RO | Agenția Națională a Medicamentului și a Dispozitivelor Medicale | Identifier(s): W66879001, W66880001, W66881001, W66882001 |
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