This brand name is authorized in Hong Kong, Singapore
The drug TS-ONE contains a combination of these active pharmaceutical ingredients (APIs):
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1
UNII UA8SE1325T - GIMERACIL
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2
UNII 4R7FFA00RX - OTERACIL POTASSIUM
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3
Tegafur
UNII 1548R74NSZ - TEGAFUR
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Tegafur is a prodrug of 5-FU with good oral bioavailability. Following oral administration, tegafur is gradually converted to 5-FU in vivo, mainly by CYP2A6 enzyme activity in the liver. 5-FU is metabolised by the liver enzyme DPD. 5-FU is activated within cells by phosphorylation to its active metabolite, 5-fluoro-deoxyuridine-monophosphate (FdUMP). FdUMP and reduced folate are bound to thymidylate synthase leading to formation of a ternary complex which inhibits DNA synthesis. In addition, 5-fluorouridine-triphosphate (FUTP) is incorporated into RNA causing disruption of RNA functions. |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01BC53 | Tegafur, combinations | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BC Pyrimidine analogues |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: HK | Department of Health Drug Office | Identifier(s): 61181, 61182 |
| Country: SG | Health Sciences Authority | Identifier(s): 13672P, 13673P |
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