This brand name is authorized in Austria, Estonia, Spain, France, Croatia, Ireland, Italy, Japan, Lithuania, United States
The drug UPLIZNA contains one active pharmaceutical ingredient (API):
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1
Inebilizumab
UNII 74T7185BMM - INEBILIZUMAB
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Inebilizumab is a monoclonal antibody that specifically binds to CD19, a cell surface antigen present on pre-B and mature B-cell lymphocytes, including plasmablasts and some plasma cells. Following cell surface binding to B lymphocytes, inebilizumab supports antibody-dependent cellular cytolysis (ADCC) and antibody-dependent cellular phagocytosis (ADCP). B cells are believed to play a central role in the pathogenesis of NMOSD. The precise mechanism by which inebilizumab exerts its therapeutic effects in NMOSD is unknown. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| UPLIZNA Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| UPLIZNA Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L04AG10 | L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AG Monoclonal antibodies | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: EE | Ravimiamet | Identifier(s): 1836547, 1881806 |
| Country: ES | Centro de información online de medicamentos de la AEMPS | Identifier(s): 1211602001 |
| Country: FR | Base de données publique des médicaments | Identifier(s): 60878038 |
| Country: IT | Agenzia del Farmaco | Identifier(s): 050085012 |
| Country: JP | 医薬品医療機器総合機構 | Identifier(s): 6399429A1026 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1094784 |
| Country: US | FDA, National Drug Code | Identifier(s): 72677-551 |
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