VARGATEF

This brand name is authorized in Austria, Croatia, Cyprus, Ecuador, Estonia, France, Hong Kong SAR China, Ireland, Italy, Lithuania, Netherlands, Poland, Romania, Spain, Turkey, UK.

Active ingredients

The drug VARGATEF contains one active pharmaceutical ingredient (API):

1	Nintedanib UNII G6HRD2P839 - NINTEDANIB
	Nintedanib is a triple angiokinase inhibitor blocking vascular endothelial growth factor receptors (VEGFR 1-3), platelet-derived growth factor receptors (PDGFR α and β) and fibroblast growth factor receptors (FGFR 1-3) kinase activity. Nintedanib binds competitively to the adenosine triphosphate (ATP) binding pocket of these receptors and blocks the intracellular signalling which is crucial for the proliferation and survival of endothelial as well as perivascular cells (pericytes and vascular smooth muscle cells).
	Read more about Nintedanib

Medication package inserts

Below package inserts are available for further reading:

Document	Type	Information Source
VARGATEF Soft capsule	MPI, EU: SmPC	European Medicines Agency (EU)

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC Group		Classification
L01EX09		L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EX Other protein kinase inhibitors
Discover more medicines within L01EX09

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	1235-MEE-0815, 1303-MEE-0915
EE	Ravimiamet	1670677, 1670688, 1670699
ES	Centro de información online de medicamentos de la AEMPS	114954003, 114954004
FR	Base de données publique des médicaments	65642038, 69324684
GB	Medicines & Healthcare Products Regulatory Agency	287824, 287827
HK	Department of Health Drug Office	64395, 64396
IE	Health Products Regulatory Authority	88458, 88459
IT	Agenzia del Farmaco	043782010, 043782022, 043782034, 043782046
LT	Valstybinė vaistų kontrolės tarnyba	1075089, 1075090, 1075091, 1075092
NL	Z-Index G-Standaard, PRK	122750, 127337
PL	Rejestru Produktów Leczniczych	100332696, 100332704
RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	W61687001, W61687002, W61687003, W61688001
TR	İlaç ve Tıbbi Cihaz Kurumu	8699693190048, 8699693190055, 8699693190062