VENCLEXTA

This brand name is authorized in Australia, Brazil, Canada, Ecuador, Hong Kong, Israel, Japan, New Zealand, Singapore, United States

Active ingredients

The drug VENCLEXTA contains one active pharmaceutical ingredient (API):

1 Venetoclax UNII N54AIC43PW - VENETOCLAX

Venetoclax is a potent, selective inhibitor of B-cell lymphoma (BCL)-2, an anti-apoptotic protein. Overexpression of BCL-2 has been demonstrated in CLL and AML cells where it mediates tumour cell survival and has been associated with resistance to chemotherapeutics. Venetoclax binds directly to the BH3-binding groove of BCL-2, displacing BH3 motif-containing pro-apoptotic proteins like BIM, to initiate mitochondrial outer membrane permeabilization (MOMP), caspase activation, and programmed cell death. Read about Venetoclax

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
VENCLEXTA Film coated tablet	FDA, National Drug Code (US)	MPI, US: SPL/PLR

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
L01XX52		L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XX Other antineoplastic agents
Discover more medicines within L01XX52

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: AU	Pharmaceutical Benefits Scheme	Identifier(s): 11624T, 11630D, 11639N, 11648C, 12188L, 12199C, 12205J
Country: BR	Câmara de Regulação do Mercado de Medicamentos	Identifier(s): 543718100003502, 543718100003602, 543718100003702, 543718100003802
Country: CA	Health Products and Food Branch	Identifier(s): 02458039, 02458047, 02458055, 02458063
Country: EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	Identifier(s): 5500-MEE-0920, 5506-MEE-0920, 5514-MEE-0920
Country: HK	Department of Health Drug Office	Identifier(s): 65283, 65284, 65285
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 7986, 7987, 7988
Country: JP	医薬品医療機器総合機構	Identifier(s): 4291062F1020, 4291062F2027, 4291062F3023
Country: NZ	Medicines and Medical Devices Safety Authority	Identifier(s): 18920, 18928, 18929, 19322
Country: SG	Health Sciences Authority	Identifier(s): 15265P, 15266P, 15267P
Country: US	FDA, National Drug Code	Identifier(s): 0074-0561, 0074-0566, 0074-0576