VENCLEXTA

This brand name is authorized in Australia, Brazil, Canada, Ecuador, Hong Kong SAR China, Israel, Japan, New Zealand, Singapore, United States.

Active ingredients

The drug VENCLEXTA contains one active pharmaceutical ingredient (API):

1
UNII N54AIC43PW - VENETOCLAX
 

Venetoclax is a potent, selective inhibitor of B-cell lymphoma (BCL)-2, an anti-apoptotic protein. Overexpression of BCL-2 has been demonstrated in CLL and AML cells where it mediates tumour cell survival and has been associated with resistance to chemotherapeutics. Venetoclax binds directly to the BH3-binding groove of BCL-2, displacing BH3 motif-containing pro-apoptotic proteins like BIM, to initiate mitochondrial outer membrane permeabilization (MOMP), caspase activation, and programmed cell death.

 
Read more about Venetoclax

Medication package inserts

Below package inserts are available for further reading:

Document Type Information Source  
 VENCLEXTA Film coated tablet MPI, US: SPL/PLR FDA, National Drug Code (US)

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC Group Classification
L01XX52 L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XX Other antineoplastic agents
Discover more medicines within L01XX52

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
AU Pharmaceutical Benefits Scheme 11624T, 11630D, 11639N, 11648C, 12188L, 12199C, 12205J
BR Câmara de Regulação do Mercado de Medicamentos 543718100003502, 543718100003602, 543718100003702, 543718100003802
CA Health Products and Food Branch 02458039, 02458047, 02458055, 02458063
EC Agencia Nacional de Regulación, Control y Vigilancia Sanitaria 5500-MEE-0920, 5506-MEE-0920, 5514-MEE-0920
HK Department of Health Drug Office 65283, 65284, 65285
IL מִשְׂרַד הַבְּרִיאוּת 7986, 7987, 7988
JP 医薬品医療機器総合機構 4291062F1020, 4291062F2027, 4291062F3023
NZ Medicines and Medical Devices Safety Authority 18920, 18928, 18929, 19322
SG Health Sciences Authority 15265P, 15266P, 15267P
US FDA, National Drug Code 0074-0561, 0074-0566, 0074-0576

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