This brand name is authorized in Austria, Croatia, Estonia, France, Ireland, Italy, Japan, Lithuania, Poland, Romania, Spain.
The drug VOXZOGO contains one active pharmaceutical ingredient (API):
1
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UNII
7SE5582Q2P - VOSORITIDE
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Vosoritide is a modified type C natriuretic peptide (CNP). In patients with achondroplasia, endochondral bone growth is negatively regulated due to a gain of function mutation in fibroblast growth factor receptor 3 (FGFR3). Binding of vosoritide to natriuretic peptide receptor-B (NPR-B) antagonises FGFR3 downstream signalling by inhibiting the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in the mitogen-activated protein kinase (MAPK) pathway at the level of rapidly accelerating fibrosarcoma serine/threonine protein kinase (RAF-1). As a result, vosoritide, like CNP, acts as a positive regulator of endochondral bone growth as it promotes chondrocyte proliferation and differentiation. |
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Below package inserts are available for further reading:
| Document | Type | Information Source | |
|---|---|---|---|
| VOXZOGO Powder and solvent for solution for injection | MPI, EU: SmPC | European Medicines Agency (EU) |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC Group | Classification | |
|---|---|---|
| M05BX07 | M Musculo-skeletal system → M05 Drugs for treatment of bone diseases → M05B Drugs affecting bone structure and mineralization → M05BX Other drugs affecting bone structure and mineralization | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| EE | Ravimiamet | 1861152, 1861163, 1861174 |
| ES | Centro de información online de medicamentos de la AEMPS | 1211577001, 1211577002, 1211577003 |
| FR | Base de données publique des médicaments | 60787186, 64530919, 68092884 |
| IT | Agenzia del Farmaco | 049692015, 049692027, 049692039 |
| JP | 医薬品医療機器総合機構 | 3999465D1028, 3999465D2024, 3999465D3020 |
| LT | Valstybinė vaistų kontrolės tarnyba | 1093281, 1093282, 1093283 |
| PL | Rejestru Produktów Leczniczych | 100457685, 100457692, 100457712 |
| RO | Agenția Națională a Medicamentului și a Dispozitivelor Medicale | W68898001, W68899001, W68900001 |
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