XGEVA

This brand name is authorized in Austria, Australia, Brazil, Canada, Cyprus, Ecuador, Estonia, Spain, Finland, France, Hong Kong, Croatia, Ireland, Israel, Italy, Lithuania, Netherlands, New Zealand, Poland, Romania, Singapore, Turkey, United Kingdom, United States

Active ingredients

The drug XGEVA contains one active pharmaceutical ingredient (API):

1 Denosumab UNII 4EQZ6YO2HI - DENOSUMAB

Denosumab is a human monoclonal antibody (IgG2) that targets and binds with high affinity and specificity to RANKL, preventing activation of its receptor, RANK, on the surface of osteoclast precursors and osteoclasts. Prevention of the RANKL/RANK interaction inhibits osteoclast formation, function and survival, thereby decreasing bone resorption in cortical and trabecular bone. Read about Denosumab

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
M05BX04	Denosumab	M Musculo-skeletal system → M05 Drugs for treatment of bone diseases → M05B Drugs affecting bone structure and mineralization → M05BX Other drugs affecting bone structure and mineralization
Discover more medicines within M05BX04

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: AU	Pharmaceutical Benefits Scheme	Identifier(s): 10061M, 5110Y
Country: BR	Câmara de Regulação do Mercado de Medicamentos	Identifier(s): 544116090003617
Country: CA	Health Products and Food Branch	Identifier(s): 02368153
Country: EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	Identifier(s): 30338-10-13
Country: EE	Ravimiamet	Identifier(s): 1536982, 1536993, 1555354
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 11703001
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 537305
Country: FR	Base de données publique des médicaments	Identifier(s): 65243459
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 193762
Country: HK	Department of Health Drug Office	Identifier(s): 61163
Country: IE	Health Products Regulatory Authority	Identifier(s): 88309
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 6929
Country: IT	Agenzia del Farmaco	Identifier(s): 041300017, 041300029
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1061806, 1061807, 1065618
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 100420
Country: NZ	Medicines and Medical Devices Safety Authority	Identifier(s): 15296
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100251058
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W57534001
Country: SG	Health Sciences Authority	Identifier(s): 14116P
Country: TR	İlaç ve Tıbbi Cihaz Kurumu	Identifier(s): 8699862770125, 8699862770132
Country: US	FDA, National Drug Code	Identifier(s): 55513-730