Specific codes in ICD-10 are unique alphanumeric designations used to identify and categorize diseases, disorders, and conditions. They consist of 3-5 characters, including both letters and numbers, that provide a high level of detail and specificity.
| Language | Translation |
|---|---|
English
|
Letterer-Siwe disease |
French
|
Histiocytose à cellules de Langerhans multifocale et multisystémique (disséminée) [Maladie de Letterer-Siwe] |
| Level | Code | Title | |
|---|---|---|---|
| 1 | II | Neoplasms | |
| 2 | C00-C97 | Malignant neoplasms | |
| 3 | C81-C96 | Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue | |
| 4 | C96 | Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue | |
| 5 | C96.0 | Letterer-Siwe disease |
| Active Ingredient | Description | |
|---|---|---|
| Ifosfamide |
Ifosfamide is an antineoplastic, a cytotoxic alkylating agent. It is a prodrug and shows no in vitro cytotoxic activity until activated by microsomal enzymes. The cytotoxic activity of ifosfamide (alkylation of the nucleophilic centres in the cells) is associated with the activated oxazaphosphorine ring hydroxylated at the C4 atom which interacts with DNA-DNA cross linking. This activity manifests itself by blocking the late S and early G2 phases of the cell cycle. |
