Plaque psoriasis

Active Ingredient: Tildrakizumab

Indication for Tildrakizumab

Population group: only adults (18 years old or older)

Tildrakizumab is indicated for the treatment of adults with moderate to severe plaque psoriasis who are candidates for systemic therapy.

For this indication, competent medicine agencies globally authorize below treatments:

100 mg at weeks 0 and 4 and every 12 weeks thereafter

Route of admnistration

Subcutaneous

Defined daily dose

100 - 100 mg

Dosage regimen

From 100 To 100 mg once every day

Detailed description

The recommended dose of tildrakizumab is 100 mg by subcutaneous injection at weeks 0 and 4 and every 12 weeks thereafter. In patients with certain characteristics (e.g. high disease burden, body weight ≥90 kg) 200 mg may provide greater efficacy.

Consideration should be given to discontinuing treatment in patients who have shown no response after 28 weeks of treatment. Some patients with initial partial response may subsequently improve with continued treatment beyond 28 weeks.

Dosage considerations

Tildrakizumab is administered by subcutaneous injection. Injection sites should be alternated. Tildrakizumab should not be injected into areas where the skin is affected by plaque psoriasis or is tender, bruised, red, hard, thick, or scaly.

Active ingredient

Tildrakizumab

Tildrakizumab is a humanized IgG1/k monoclonal antibody that specifically binds to the p19 protein subunit of the interleukin-23 (IL-23) cytokine without binding to IL-12 and inhibits its interaction with the IL-23 receptor. Tildrakizumab inhibits the release of proinflammatory cytokines and chemokines.

Read more about Tildrakizumab

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