Carcinoma of the prostate

Active Ingredient: Estramustine

Indication for Estramustine

Population group: men, only adults (18 years old or older)

Carcinoma of the prostate, especially in cases unresponsive to, or relapsing after, treatment by conventional oestrogens (stilboestrol, polyoestradiol phosphate etc.) or by orchidectomy.

For this indication, competent medicine agencies globally authorize below treatments:

140-1,400 mg in divided doses daily

Route of admnistration

Oral

Defined daily dose

140 - 1,400 mg

Dosage regimen

From 46.667 To 466.667 mg 3 time(s) per day every day

Detailed description

Dosage range may be from 140 to 1,400 mg a day by mouth. The capsules should be taken not less than 1 hour before or 2 hours after meals. Milk, milk products or drugs containing calcium, magnesium or aluminium (e.g. antacids) must not be taken simultaneously with estramustine. Standard starting dosage is 560-840 mg a day in divided doses with later adjustment according to response and gastrointestinal tolerance.

Dosage considerations

It should be taken not less than 1 hour before or 2 hours after meals.

Active ingredient

Estramustine

Estramustine is a chemical compound of oestradiol and nitrogen mustard. It is effective in the treatment of advanced prostatic carcinoma. Estramustine has a dual mode of action. The intact molecule acts as an anti-miotic agent; after hydrolysis of the carbamate ester, the metabolites act to bridge the released oestrogens and exert an anti-gonadotrophic effect.

Read more about Estramustine

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