Active Ingredient: Atezolizumab
Atezolizumab, in combination with bevacizumab, is indicated for the treatment of adult patients with advanced or unresectable HCC who have not received prior systemic therapy.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Intravenous, 840 milligrams atezolizumab, once every 2 weeks.
Regimen B: Intravenous, 1,200 milligrams atezolizumab, once every 3 weeks.
Regimen C: Intravenous, 1,680 milligrams atezolizumab, once every 4 weeks.
Atezolizumab should be administered prior to bevacizumab when given on the same day. Bevacizumab is administered at 15 mg/kg body weight (bw) every 3 weeks.
Until loss of clinical benefit or unmanageable toxicity.
If a planned dose of atezolizumab is missed, it should be administered as soon as possible. The schedule of administration must be adjusted to maintain the appropriate interval between doses.
Dose reductions of atezolizumab are not recommended.
The infusions must not be administered as an intravenous push or bolus.
The initial dose of atezolizumab must be administered over 60 minutes. If the first infusion is well tolerated, all subsequent infusions may be administered over 30 minutes.
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