Hormone receptor positive malignant neoplasm of breast

Active Ingredient: Letrozole

Indication for Letrozole

Population group: women, only adults (18 years old or older)

Adjuvant treatment of postmenopausal women with hormone receptor positive invasive early breast cancer.
Extended adjuvant treatment of hormone-dependent-invasive breast cancer in postmenopausal women who have received prior standard adjuvant tamoxifen therapy for 5 years.
First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer.
Advanced breast cancer after relapse or disease progression, in women with natural or artificially induced postmenopausal endocrine status, who have previously been treated with anti-oestrogens.
Neo-adjuvant treatment of postmenopausal women with hormone receptor positive, HER-2 negative breast cancer where chemotherapy is not suitable and immediate surgery not indicated.

For this indication, competent medicine agencies globally authorize below treatments:

2.5 mg once daily

Route of admnistration

Oral

Defined daily dose

2.5 - 2.5 mg

Dosage regimen

From 2.5 To 2.5 mg once every day

Detailed description

The recommended dose of Letrozole is 2.5 mg once daily. No dose adjustment is required for elderly patients.

In patients with advanced or metastatic breast cancer, treatment with letrozole should continue until tumour progression is evident.

In the adjuvant and extended adjuvant setting, treatment with letrozole should continue for 5 years or until tumour relapse occurs, whichever is first.

In the adjuvant setting a sequential treatment schedule (letrozole 2 years followed by tamoxifen 3 years) could also be considered. In the neoadjuvant setting, treatment with letrozole could be continued for 4 to 8 months in order to establish optimal tumour reduction. If the response is not adequate, treatment with letrozole should be discontinued and surgery scheduled and/or further treatment options discussed with the patient.

Dosage considerations

Can be taken with or without food.

Active ingredient

Letrozole
Letrozole is a non-steroidal aromatase inhibitor. It inhibits the aromatase enzyme by competitively binding to the haem of the aromatase cytochrome P450, resulting in a reduction of oestrogen biosynthesis in all tissues where present. Read more about Letrozole

Related medicines

Summary of Product Characteristics (SPC) 2018: LETROZOLE / GLENMARK Film-coated tablets

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