Osteoporosis

Active Ingredient: Denosumab

Indication for Denosumab

Population group: only adults (18 years old or older)

Treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. In postmenopausal women denosumab significantly reduces the risk of vertebral, non-vertebral and hip fractures.

For this indication, competent medicine agencies globally authorize below treatments:

60 mg once every 6 months

Route of admnistration

Subcutaneous

Defined daily dose

60 - 60 mg

Dosage regimen

From 60 To 60 mg once every 180 day(s)

Loading dose

60 mg

Detailed description

The recommended dose of Prolia is 60 mg administered as a single subcutaneous injection once every 6 months into the thigh, abdomen or upper arm. Patients must be adequately supplemented with calcium and vitamin D.

Dosage considerations

Subcutaneous injection once every 6 months into the thigh, abdomen or upper arm.

Active ingredient

Denosumab

Denosumab is a human monoclonal antibody (IgG2) that targets and binds with high affinity and specificity to RANKL, preventing activation of its receptor, RANK, on the surface of osteoclast precursors and osteoclasts. Prevention of the RANKL/RANK interaction inhibits osteoclast formation, function and survival, thereby decreasing bone resorption in cortical and trabecular bone.

Read more about Denosumab

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