Cervical cancer

Active Ingredient: Cemiplimab

Indication for Cemiplimab

Population group: women, only adults (18 years old or older)
Therapeutic intent: Curative procedure

Cemiplimab as monotherapy is indicated for the treatment of adult patients with recurrent or metastatic cervical cancer and disease progression on or after platinum-based chemotherapy.

For this indication, competent medicine agencies globally authorize below treatments:

350 mg once every 3 weeks

For:

Dosage regimens

Intravenous, 350 milligrams cemiplimab, once every 3 weeks.

Detailed description

The recommended dose is 350 mg cemiplimab every 3 weeks (Q3W) administered as an intravenous infusion over 30 minutes.

Treatment may be continued until disease progression or unacceptable toxicity.

Elderly

No dose adjustment is recommended for elderly patients. Cemiplimab exposure is similar across all age groups. Data are limited in patients ≥75 years on cemiplimab monotherapy.

Dosage considerations

Cemiplimab is administered by intravenous infusion over 30 minutes through an intravenous line containing a sterile, non-pyrogenic, low-protein binding, in-line or add-on filter (0.2 micron to 5 micron pore size).

Other medicinal products should not be co-administered through the same infusion line.

Active ingredient

Cemiplimab

Cemiplimab is a fully human immunoglobulin G4 (IgG4) monoclonal antibody that binds to the programmed cell death-1 (PD-1) receptor and blocks its interaction with its ligands PD-L1 and PD-L2. Cemiplimab potentiates T cell responses, including anti-tumour responses, through blockade of PD-1 binding to PD-L1 and PD-L2 ligands.

Read more about Cemiplimab

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