Multi-drug resistant tuberculosis (MDR-TB)

Active Ingredient: Delamanid

Indication for Delamanid

Population group: only adults (18 - 65 years old)
Therapeutic intent: Curative procedure

Delamanid is indicated for use as part of an appropriate combination regimen for pulmonary multi-drug resistant tuberculosis (MDR-TB) in adults when an effective treatment regimen cannot otherwise be composed for reasons of resistance or tolerability.

For this indication, competent medicine agencies globally authorize below treatments:

200 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

200 - 200 mg

Dosage regimen

From 100 To 100 mg 2 time(s) per day every day for 168 day(s)

Detailed description

The recommended dose for adults is 100 mg twice daily for 24 weeks.

Dosage considerations

Delamanid should be taken with food.

Active ingredient

Delamanid

The pharmacological mode of action of delamanid involves inhibition of the synthesis of the mycobacterial cell wall components, methoxy-mycolic and keto-mycolic acid. The identified metabolites of delamanid do not show anti-mycobacterial activity.

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