Renal cell carcinoma

Active Ingredient: Nivolumab

Indication for Nivolumab

Population group: only adults (18 years old or older)
Therapeutic intent: Adjunct intent

Nivolumab in combination with ipilimumab is indicated for the first-line treatment of adult patients with intermediate/poor-risk advanced renal cell carcinoma.

For this indication, competent medicine agencies globally authorize below treatments:

3 mg/kg every 3 weeks for the first 4 doses and thereafter 240 mg every 2 weeks or at 480 mg every 4 weeks

For:

Dosage regimens

Regimen A: Intravenous, 3 milligrams nivolumab per kilogram of body weight, once every 3 weeks, 4 doses in total, over the duration of 15 weeks. Afterwards, intravenous, 240 milligrams nivolumab, once every 2 weeks.

Regimen B: Intravenous, 3 milligrams nivolumab per kilogram of body weight, once every 3 weeks, 4 doses in total, over the duration of 18 weeks. Afterwards, intravenous, 480 milligrams nivolumab, once every 4 weeks.

Detailed description

The recommended dose is 3 mg/kg nivolumab in combination with 1 mg/kg ipilimumab administered intravenously every 3 weeks for the first 4 doses. This is then followed by a second phase in which nivolumab monotherapy is administered intravenously at either 240 mg every 2 weeks or at 480 mg every 4 weeks, as presented in the table below. For the monotherapy phase, the first dose of nivolumab should be administered;

  • 3 weeks after the last dose of the combination of nivolumab and ipilimumab if using 240 mg every 2 weeks; or
  • 6 weeks after the last dose of the combination of nivolumab and ipilimumab if using 480 mg every 4 weeks.

Recommended doses and infusion times for intravenous administration of nivolumab in combination with ipilimumab for RCC:

 Combination phase, every
3 weeks for 4 dosing cycles
Monotherapy phase
Nivolumab 3 mg/kg over 30 minutes 240 mg every 2 weeks over 30 minutes or
480 mg every 4 weeks over 60 minutes
Ipilimumab 1 mg/kg over 30 minutes-

Dosage considerations

Nivolumab must not be administered as an intravenous push or bolus injection.

Active ingredient

Nivolumab

Nivolumab is a human immunoglobulin G4 (IgG4) monoclonal antibody (HuMAb), which binds to the programmed death-1 (PD-1) receptor and blocks its interaction with PD-L1 and PD-L2. Nivolumab potentiates T-cell responses, including anti-tumour responses, through blockade of PD-1 binding to PD-L1 and PD-L2 ligands. In syngeneic mouse models, blocking PD-1 activity resulted in decreased tumour growth.

Read more about Nivolumab

Related medicines

Develop a tailored medication plan for your case, considering factors such as age, gender, and health history

Ask the Reasoner

Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.