Relapsed or refractory mantle cell lymphoma (MCL)

Active Ingredient: Ibrutinib

Indication for Ibrutinib

Population group: only adults (18 years old or older)

Ibrutinib as a single agent is indicated for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL).

For this indication, competent medicine agencies globally authorize below treatments:

560 mg once daily

Route of admnistration

Oral

Defined daily dose

560 - 560 mg

Dosage regimen

From 560 To 560 mg once every day

Detailed description

The recommended dose for the treatment of MCL is 560 mg (four capsules) once daily.

Active ingredient

Ibrutinib

Ibrutinib is a potent, small-molecule inhibitor of Bruton’s tyrosine kinase (BTK). BTK, a member of the Tec kinase family, is an important signalling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways. Preclinical studies have shown that ibrutinib effectively inhibits malignant B-cell proliferation and survival in vivo as well as cell migration and substrate adhesion in vitro.

Read more about Ibrutinib

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